4. Bring a large pot of water to a boil and salt lightly. Drop in the penne and cook until al dente, about 8 minutes. (It should be slightly undercooked to allow for baking time.) Drain the penne and place in a large bowl. Pour the sauce over and toss in the cheeses (reserve a handful of Parmesan). Season to taste with salt and pepper.
5. Pour the mixture into the baking dish, making sure to include all of the sauce. Sprinkle with the garlic bread crumbs and remaining Parmesan and bake until golden and bubbling, about 40 minutes.