And Matthews stopped him.
The Packers took over on downs and ran out the clock.
"In the situation they were in, it seemed to be their safest bet," said Matthews, who inhaled a deep breath and added: "I am gassed!"
Understandably so, given that he and his Green Bay teammates had prepared for Eagles starting quarterback Kevin Kolb. When Kolb was sidelined with a concussion and replaced by Vick in the second half, the Packers suddenly found themselves in a track meet.
Vick gained 103 yards on 11 carries, the 10th time in his career that he has gained 100 or more rushing yards. He also completed 16 of 24 pass attempts for 175 yards and one touchdown.
"We prepared for Michael Vick more in the Wildcat type packages," said Packers coach Mike McCarthy. "And I thought he did an excellent job. He adds a whole other dimension to the game, particularly with his running skills and his ability to extend plays."
McCarthy heaped accolades on his defense for its performance on the fourth-and-1 stop. "We stressed all of training camp playing adversity defense and to end the game on fourth-and-1 with a quarterback in the backfield [who has] a number of different options, that is big play by our defense. Michael Vick is still a very dynamic player."
The players who spent the day chasing him agreed. Green Bay linebacker Nick Barnett said Vick is still "comparable" to the player he was early in his career.
"I have always liked Vick," Barnett said of the Eagles backup, who was signed following a prison sentence for running a dogfighting operation. "He played a hell of a game."
Green Bay defensive end Cullen Jenkins added: "He will be a starting quarterback again in the league. When he was out there, I was kind of hoping the other quarterback would come back into the game."
What did the Packers think of "the other quarterback?" Under pressure from the beginning of the game, Kolb completed five of 10 pass attempts for 24 yards before he was sidelined. He had no touchdown passes.
McCarthy said he has "got a lot of excellent football in front of him." He added, "I think he is going to be everything [the Eagles] think he will be."
Matthews said, "You have to keep a spy on him and keep the integrity of the rush lanes. He is hard to bring down. Playing against him is very hard."