Then there is the Pennsylvania House, which was reclaimed by Republicans, by a majority of at least 111-92, in Tuesday's election, while the state Senate remained in GOP hands.
For years, Philadelphia has had no Republican senators. And now, given the defeat Tuesday of longtime Northeast Rep. John M. Perzel, the city will have just two Republican representatives in the House - John Taylor of Port Richmond and Dennis O'Brien of the Far Northeast - leaving the city with just a small voice among Pennsylvania's new power brokers.
"My job is to remind people around the state of the importance of Philadelphia," said Taylor, who noted that almost every Southeast suburban legislator or a family member either works in Philadelphia, went to school there, or has been to a doctor there.
Also, come January, the city's most influential lawmaker, Democratic Rep. Dwight Evans, will have to cede control of the purse strings at the House Appropriations Committee.
That's not all.
In Washington, the city's clout will likewise take a nosedive. Longtime Sen. Arlen Specter, a Republican-turned-Democrat, is serving his final months after his primary defeat and will be replaced by Republican Pat Toomey - a freshman who will be in that chamber's minority party.
With the U.S. House switching from Democratic to GOP control, the city will have nobody to represent its voice in the majority party, since all three of its House members - Bob Brady, Chaka Fattah, and Allyson Y. Schwartz - are Democrats.
Taken together, all of those Election Day changes, Democratic consultant Larry Ceisler said, make Philadelphia one big loser.
"If you don't have a seat at the table, you don't have the same political leverage," he said. "This is one of the reasons Philadelphia needs a vibrant and competitive Republican Party, for times like this."