The Dragons rallied from a late four-point deficit to pick up their first conference road win of the season. Nacickaite put together her fourth double-double of the season with 18 points and 10 rebounds and hit 2 of 2 three-pointers.
Taysha Pye led the Tribe (1-14, 0-5) with 19 points.
Virginia 54, Penn 45 - The Quakers, down by 17 points in the second half, managed to cut the deficit to three points with under three minutes to play, but couldn't get any closer in a loss to the Cavaliers (11-8) in Charlottesville, Va.
Penn (5-8) was led by freshman Alyssa Baron, who scored 13 points, while Brianna Bradford tallied 11 points. Jess Knapp and Erin Power led the Quakers with eight rebounds apiece.
DePaul 64, Villanova 45 - Keisha Hampton scored 18 points to lead the No. 14 Blue Demons over the host Wildcats. DePaul (17-2, 5-0 Big East) has won 14 of its last 15.
Katherine Harry had 14 points and Felicia Chester added 13 for the Blue Demons, one of three teams undefeated in league play along with No. 2 UConn and Rutgers.
Lindsay Kimmel had 12 points to pace Villanova (8-9, 0-4), which has lost three of its last four.
District of Columbia 59, Philadelphia University 52 - The Rams (7-6) lost their third straight, falling to the Firebirds (11-6) at the Gallagher Athletic Center.
PhilaU was led by junior guard Stephanie Agger, who scored 17 points. Teammate Kristen Blye (Downingtown East) added 10 points.
PhilaU coach Tom Shirley will continue his hunt for 600 wins on Wednesday vs. Chestnut Hill College.
Elsewhere: Penn State's Maggie Lucas (Germantown Academy) scored 22 points in the Nittany Lions' 83-62 win over Illinois. Lucas nailed six three-pointers to set a school freshman record with 66 treys. . . . Danielle Parker had a career-high 18 points but Delaware lost to Old Dominion, 62-59.
Mel Greenberg contributed to this article.