We do know that one of the older antihistamines, Periactin (cyproheptadine), is an appetite stimulant and has been used as such. We also have seen that for a small percentage of people, antihistamines can increase appetite. At the same time, we also see many folks who take antihistamines - especially the newer ones like Claritin, Allegra, and Zyrtec - with no reported weight gain. Perhaps the sedating effects of certain antihistamines may keep some in the house, with a less active lifestyle and more contact time with their kitchen as contributing factors to their weight gain. Another possible explanation for the antihistamine/obesity association may be that certain obese folks may have more issues with allergies and therefore are more likely to be taking an antihistamine.
For those who have allergies all year long, allergy desensitization shots may be a helpful long-term strategy. Intranasal steroid and antihistamine sprays as well as antihistamine eye drops may be other options for some. In the end, one has to balance the huge benefit of symptomatic relief from allergies against a small potential risk of weight gain.
The scoop on BOOP
Q: Several years ago, I was diagnosed with "BOOP" - Bronchiolitis Obliterans Organizing Pneumonia. I was placed on a prednisone taper over 10 months. Two months later, it started all over again and I needed another 10-month prednisone taper. My initial symptoms were loss of weight and shortness of breath. My doctor says they don't know what causes BOOP. Can tell me more about my illness?
