The game was one of two morning football matchups on the opening day of the season.
McDevitt notched four of its six scores in the second half. The Lancers totaled 391 yards (332 rushing, 59 passing) on offense.
McDevitt forced four turnovers, including interceptions by linebacker Darren Wright and safety Dom Davis.
In the fourth quarter, junior tailback Gerald Fuller (three carries for 87 yards) and senior quarterback Sean Bryson scored on runs of 1 and 8 yards, respectively.
For the Lions, of the Bicentennial Athletic League, junior QB Lance Gifford hit on 5 of 8 passes for 90 yards.
Special-teams player Martin Stanton and strong safety Mark Griffin made fumble recovers for McDevitt.
The Lancers lead the series, 4-0.
Bishop McDevitt 130819-40
Lower Moreland 0000-0
BM: Keith Young 49 run (Sean Bryson kick)
BM: Keith Young 1 run (kick failed)
BM: Keith Young 20 run (Conners run)
BM: Keith Young 12 run (kick failed)
BM: Gerald Fuller 1 run (Bryson kick)
BM: Sean Bryson 8 run (kick failed)
Contact staff writer Rick O'Brien at 610-313-8019, robrien@phillynews.com, or @ozoneinq on Twitter.