Blandon, a 5-foot-11, 176-pound senior, ran 10 times for 163 yards and three touchdowns as Camden Catholic, the No. 9 team in The Inquirer Top 10, improved to 4-0 overall and 2-0 in the division.
Seneca dropped to 2-3 overall, 2-2 in the division.
Jarred Alwan, a 6-1, 220-pound junior, carried 10 times for 75 yards and two touchdowns. Senior quarterback Pete Galiano was 7-for-10 passing for 160 yards and also had an 80-yard touchdown run nullified because of a penalty.
"We've got a running attack, and we've got a passing attack," Blandon said.
Blandon, who had an interception, also was a standout on defense along with Alwan, and junior linebackers Sean Collins and Will Jackson.
Camden Catholic, which will play Delsea, Pennsauken, and Moorestown in its next three games, has allowed just 12 points all season. The Irish have scored 171.
"Seneca is a good football team, and they really run a nice wing-T," Camden Catholic coach Gil Brooks said. "Our kids did a nice job. We've got a few kids back on defense, and if you have a good defense, you have a chance to have a good football team."
Camden Catholic's offensive line, led by center Jeff Miller, cleared the way for Blandon and Alwan and gave Galiano lots of time and room to operate.
"They're still kind of young," Brooks said of the Irish offensive line, which includes four juniors. "But they've really been working hard. They did a great job tonight, especially in the second half."
Camden Catholic 7 7 20 6 – 40
Seneca 0 0 0 0 – 0
CC: Mike Blandon 53 run (Kandeh Kamara kick)
CC: Jarred Alwan 4 run (Kamara kick)
CC: Blandon 5 run (Kamara kick)
CC: Alwan 46 run (Kamara kick)
CC: Blandon 79 run (kick failed)
CC: Jarret Bragg 8 run (kick failed)
Contact staff writer Phil Anastasia at 856-779-3223, panastasia@phillynews.com, or @PhilAnastasia on Twitter. Read his blog, "Jersey Side Sports," at www.philly.com/jerseysidesports