Bryzgalov, who starred in Phoenix before being acquired in June, made 20 saves and ended the Flyers' 85-game, regular-season shutout drought. It was his 24th career shutout and 16th in the last two-plus seasons.
"I can't say enough about the whole team's work ethic," said Bryzgalov, whose teammates limited the Devils' good scoring chances. "The team just played unbelievable. They worked extremely hard in the offense zone and back-checked on defense."
With a sellout crowd watching at the Prudential Center, the Flyers spoiled Pete DeBoer's first game as the Devils coach.
The Flyers took the lead with just under eight minutes left in the first period. Defenseman Matt Carle kept the puck in the zone at the blue line and rapped a pass behind the net to James van Riemsdyk, who slid a no-look pass to Giroux. The fourth-year center, skating in the left side of the right circle, rifled a shot past Martin Brodeur.
Read, who excelled on the penalty-killing unit, said his goal "lowers the shoulders a little bit, and you don't have to worry about it for now on."
After the game, he was handed the goal puck by Zack Hill, the Flyers' publicity director.
"I'll probably give it to my parents," he said. "You have to thank them as much as you can. Without them, I wouldn't be here."
Scoring against a future Hall of Famer, he added, made the goal more special.
"Before the game, a couple guys were saying, 'This is the guy you want to score your first one on,' " said Read, smiling. "The whole game, I had a feeling that something special was going to happen, and when I got that puck I almost closed my eyes - I knew it was going in."
"I'm joking," he said.
In Thursday's season-opening, 2-1 win, the Flyers waited in their locker room for 35 minutes as the game was delayed because of the Bruins' Stanley Cup championship ceremony. The Flyers came out flat before gradually taking control after Giroux's goal.
On Saturday, it was the Flyers who seized the early momentum and played a better all-around game. They outshot the Devils, 29-20.
Brodeur stopped breakaways by Andreas Nodl, Sean Couturier, and van Riemsdyk. The first two were while the Flyers were shorthanded.
Read gave the Flyers a 2-0 cushion when he took a cross from Scott Hartnell and beat Brodeur from the high slot, firing a shot that bounced off the goalie and into the net with 17 minutes, 19 seconds left in the game.
About two minutes later, Simmonds scored on the rebound - his first goal as a Flyer. Simmonds, acquired in the deal that sent captain Mike Richards to Los Angeles, later pounded David Clarkson in a fight.
Simmonds said he wasn't surprised by the Flyers' cohesiveness, even though they have nine new players.
"The majority of guys came in early this year, and I think we tried to build that camaraderie," he said. "We did a couple team-building exercises. We knew we had a lot of new guys and had to do stuff like that."
Like in the opener, Bryzgalov was sharp and in control, frequently steering rebounds to his teammates.
Bryzgalov, 31, made perhaps his best save when he got a piece of Zach Parise's tricky deflection in the closing seconds of the second period.
Acquired from the Phoenix Coyotes and then signed to a nine-year, $51 million deal, Bryzgalov notched the Flyers' first regular-season shutout since Brian Boucher blanked host Toronto, 2-0, on April 6, 2010.
With 3:59 to play, the Flyers' Jakub Voracek was driven into the boards by Bradley Mills. The boarding penalty may result in a suspension.
Contact staff writer Sam Carchidi at firstname.lastname@example.org or @BroadStBull on Twitter.