"The bar is very high," said bioethicist Jeffrey Kahn of Johns Hopkins University, who led the institute panel.
The group stopped short of recommending an outright ban, saying a handful of research projects today might still require chimps - but more important, that the animals might be needed in the future as new diseases evolve and emerge.
Animal-welfare groups welcomed the change but continue to push for Congress to pass legislation that would go a step further and phase out all invasive chimp research.
"Chimpanzees have provided limited value in research settings, and now alternative methods have been developed that will make their use all but obsolete," said Wayne Pacelle, president of the Humane Society of the United States.
Some scientists say it's not that big a change because chimp studies already were dwindling fast as researchers turned to less costly and ethically charged alternatives.
"The use of a chimpanzee in biomedical research is the rare exception," said Thomas Rowell, who directs Louisiana's New Iberia Research Center, one of five research centers that house chimps and other primate species used in both government- and privately financed studies.
It's not clear exactly how many of the nation's 937 research chimps - 612 of them owned by the NIH - are in the midst of experiments that would be affected by the new standards and could be moved into retirement instead. Most of the chimps are fairly old, as the nation has had a moratorium on breeding since 1995.
But Collins temporarily barred new government-funded studies involving chimps as his agency began implementing the recommended restrictions. Also, a working group will decide whether to phase out about 37 ongoing projects, about half of which Collins said probably don't meet the new standards.
The United States is one of only two countries known to still conduct medical research with chimpanzees; the other is Gabon, in Africa. The European Union essentially banned such research last year.
The standards wouldn't automatically apply to privately funded pharmaceutical research, although that industry, too, is shifting away from use of chimps.