Planet of the Apes: An evolution in guidelines for research on chimps

December 26, 2011|By Faye Flam, Inquirer Columnist

Chimps are about 96 percent genetically identical to humans, and like us they are self-aware enough to recognize themselves in a mirror.

But physically, we show some remarkable differences. They don't get the same kind of heart disease humans get. They develop some of the brain abnormalities associated with Alzheimer's disease, but not others. And despite being more sexually promiscuous than humans, they don't get the same sexually transmitted diseases.

They heal better than we do and don't get sleep apnea, hemorrhoids, varicose veins, or acne. They aren't vulnerable to cancers of the breast, lung, stomach, pancreas, colon, ovaries, or prostate.

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Physician-scientist Ajit Varki says these differences can be as informative as the similarities. With new restrictions expected soon on the use of chimpanzees in research, he and other scientists spoke about some types of research not mentioned in a new report, which they hope will continue or even increase.

The changes are expected to follow an Institute of Medicine report, released earlier this month, that stressed that biomedical research should be necessary, behavioral studies should be noninvasive, and animals should be housed and cared for appropriately. It was hailed as a positive step by animal-welfare advocates, such as the American Anti-Vivisection Society in Jenkintown. (According to the society's Sue Leary, there are currently no research chimpanzees in Philadelphia.)

The report said that most current research on chimpanzees is unnecessary. In response, the National Institutes of Health has called for a moratorium on new grants for chimp research until the agency can implement IOM's recommendations. But the new guidelines are not specific enough for scientists to predict which research projects will get the ax.

Some types of research should actually increase, said Varki, including studies that monitor the health of chimpanzees in research centers and sanctuaries. These, he said, can be conducted as part of the chimps' health care and can potentially benefit chimps, since they suffer their own unique set of health problems.

His bottom line is that scientists shouldn't do anything to a chimp they wouldn't be able to do ethically to a human. Researchers, he said, should consider invasiveness as well as any potential benefit to the chimps. Those criteria were not mentioned with regard to biomedical studies.

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