Additionally, Iran exerts growing pressure on Afghanistan to the east and growing influence in Iraq to the west. Tehran has even extended its horizon to Latin America, as symbolized by President Mahmoud Ahmadinejad's solidarity tour through Venezuela, Ecuador, Nicaragua, and Cuba.
Of all these clients, Syria is the most important. It's the only Arab state openly allied with non-Arab Iran. This is significant because the Arabs see the Persians as having had centuries-old designs to dominate the Middle East. Indeed, Iranian arms and trainers, transshipped to Hezbollah through Syria, have given the Persians their first outpost on the Mediterranean in 2,300 years.
But the Arab-Iranian divide is not just national/ethnic. It is sectarian. The Arabs are overwhelmingly Sunni. Iran is Shiite. The Arab states fear Shiite Iran infiltrating the Sunni homeland through (apart from Iraq) Hezbollah in Lebanon, and through Syria, run by Assad's Alawites, a heterodox offshoot of Shiism.
Which is why the fate of the Assad regime is geopolitically crucial. It is, of course, highly significant for reasons of democracy and human rights as well. Syrian Baathism, while not as capricious and deranged as the Saddam Hussein variant, runs a ruthless police state that once killed 20,000 in Hama, and has now killed more than 5,400 during the current uprising.
Human rights - decency - is reason enough to do everything we can to bring down Assad. But strategic opportunity compounds the urgency.