Six Sixers finished in double figures. Players such as Andre Iguodala and Elton Brand were able to conserve their energy, as neither played more than 25 minutes.
The Cavaliers were playing their third game in a row without rookie point guard Kyrie Irving, out with concussion-like symptoms. Making matters even worse for the Cavs was the loss of center Anderson Varejao. The top offensive rebounder in the league, Varejao, who suffered a broken wrist in the Cavs' last game, is out indefinitely.
"It is something that we are trying to work on and be consistent with all year," said Iguodala, who finished with eight points, six rebounds, and five assists.
"Last year, we had the problem of playing to the level of our competition. This year, we've been very conscious of it. We can't just bring our best game against the top teams - we've got to bring it every night, and we've been able to do that. It's something that we've really been able to improve upon."
The win ended the 76ers' first two-game losing streak of the season. The Sixers have not lost three regular-season games in a row since they dropped three straight last season from April 2 through April 6.
Jrue Holiday finished with 20 points, five assists, and four rebounds. Lou Williams finished with 19 points and five assists, and Thaddeus Young chipped in with 16 points and six rebounds.
After a physical game on Friday night against the Clippers, the Sixers welcomed facing an injury-depleted Cleveland team that simply couldn't mount much resistance.
After a sluggish start that saw the Sixers leading by just two points after the first quarter, they began the second by outscoring the Cavaliers 10-0. That prompted Cleveland coach Byron Scott to call a timeout less than two minutes into the period.
The timeout did nothing to slow the Sixers, who connected on 57 percent of their shots in the quarter. When play resumed, the Sixers eventually extended the lead to 21 points on Elton Brand's turnaround jumper with 2:39 left in the half.
The 37 points the Sixers scored in the quarter tied their previous high for the second quarter this season, achieved against Atlanta one week ago.
"I think we just got off to a good start and we were determined to have a strong game," Holiday said. "I think guys like Thad and Lou got us jump-started. It was a consistent performance."
Contact staff writer John N. Mitchell at jmitchell@philly.com. Follow him @JmitchInquirer on Twitter.
