Manson and his followers were convicted in the 1969 slaying of actress Sharon Tate and four others.
"I'm done with him," Debra Tate, the sister of the actress, said after the hearing.
For four decades, Debra Tate has traveled to whatever rural California prison has held the notorious cult leader and his band of murderous followers for hearings she said are too numerous to count.
"I've tried to take this thing that I do, that has become my lot in life, and make it have purpose," Tate, 59, said Tuesday. She was 17 in August 1969, when Manson sent his minions across Los Angeles on two nights of terror.
Under current law, inmates can be denied the chance to reapply for parole for up to 15 years. The ruling Wednesday would make Manson 92 before he could get another opportunity to make his case.
"At his age, I think he doesn't care," Deputy District Attorney Patrick Sequeira has said. "He would be lost if he got out. He's completely institutionalized."
Manson has not appeared at a parole hearing since 1997. His most recent hearing was in 2007.
Manson, however, is anything but a recluse. He has a stream of visitors who submit requests to see him, including college students writing papers about him, said Theresa Cisneros, spokeswoman for Corcoran State Prison. Manson must approve all requests.
"He has a large interested public," Cisneros said, adding that Manson receives more mail than most prisoners.
Manson has been cited twice for having smuggled cellphones. He was cited in October for having a homemade weapon.