As expected, former campaign aide Andrew Young is listed as a prosecution witness. Young handled the money for Hunter's care and falsely claimed paternity of Edwards' child. After repeatedly denying the affair, the former U.S. senator admitted the baby was his in 2010.
Key to the government's case is proving that Edwards, 58, knew about the payments, which prosecutors contend were illegal campaign donations under federal law.
The money came from Edwards' national campaign finance chairman, the late Texas lawyer Fred Baron, and campaign donor Rachel "Bunny" Mellon, an heiress and socialite who is now 101 years old. Both had already given Edwards' campaign the maximum $2,300 individual contribution allowed by federal law.
Baron's widow, Lisa Blue, is listed as a witness. Mellon is considered too frail to travel to the North Carolina courthouse from her Virginia estate, but her longtime lawyer, Alex Forger, is expected to testify.
Also on the witness list are two former members of the Edwards defense team, lawyers Wade Smith and Jim Cooney. Smith was forced to withdraw in October after prosecutors suggested he had a conflict of interest. They said he might be called to testify about a 2009 conversation he had with Forger about Edwards' knowledge of the money from Mellon.
Former Edwards press secretary Jennifer Palmieri is expected to testify she was present in an Iowa hotel room in October 2007 when wife Elizabeth Edwards confronted the candidate, Baron, and Baron's wife about the couple's support of Hunter.
According to Palmieri's account, Baron and Blue tried to calm Edwards' angry wife by saying the mistress was a "loose cannon" who had to be kept happy, lest she go to the press.
Edwards dropped out of the presidential race on Jan. 30, 2008. It has not yet been decided whether he will testify.
If convicted, Edwards faces a maximum penalty of 30 years in prison and as much as $1.5 million in fines.