Mike Piazza, Curt Schilling and Craig Biggio - none of whom have ever been linked to steroids - also will make their first appearances.
Who goes in, or is left out, and by what margin will be a fascinating tale.
What a history
The Houston Astros signed their second draft pick on Tuesday, inking Tampa Jesuit righthander Lance McCullers, a product of Florida's fertile Hillsborough County.
Among the players who got their start in the county are Fred McGriff, Gary Sheffield, Tino Martinez, Luis Gonzalez, Dwight Gooden, Howard Johnson, Brad Radke, Wade Boggs and Derek Bell.
Three others from Tampa - Tony LaRussa, Lou Piniella and Hall of Famer Al Lopez - made their mark as managers.
Not to mention George Steinbrenner, who may have been the biggest luminary of them all.
Blast from the past
With the Pittsburgh Pirates in the unaccostomed position of fielding a winning ballclub, management is bringing back two guys who were winners in the black and gold unis.
Hall of Fame second baseman Bill Mazeroski, 71, and centerfielder Bill Virdon, 81, will join the Pirates on the bench during their three-game series with Minnesota this week at the invitation of manager Clint Hurdle.
Around the bigs
Angels righthander Jerome Williams is still resting at a hospital after undergoing several tests and staying overnight. Williams complained of shortness of breath after he left his start against San Francisco.
Atlanta manager Fredi Gonzalez said righthander Brandon Beachy has a partial tear in his elbow. He did not elaborate on the severity of the injury.
Contact Don McKee at firstname.lastname@example.org.
This article contains information from the Associated Press.