On the game's first play from scrimmage, his pass was broken up by Lance Briggs. Then Chicago's Geno Hayes tipped the ball near midfield, but Jacob Tamme hauled it in for a 12-yard gain.
After a short run by Willis McGahee, Manning found Eric Decker on the left for 10 yards. A 19-yarder to Decker put the ball at the 14. But on third down at the 12, Manning was picked off when Denver's Brandon Stokley deflected a pass and Major Wright dived to grab it.
A Philly player scores
Curtis Brinkley, a West Catholic High graduate and now a running back with the San Diego Chargers, scored a touchdown late in the fourth quarter of the Chargers' 21-13 victory over the visiting Green Bay Packers.
Brinkley, who was shot twice in the shoulder in 2009 in Cheltenham, had 11 carries for 42 yards and one TD.
Brinkley, who grew up in East Falls and attended Syracuse, went undrafted before signing with the Chargers.
Robert Griffin III's debut as quarterback of the Washington Redskins went about as well as he and his coaches could have hoped.
Getting his feet wet with a 14-play sampling against the host Buffalo Bills, the highly touted rookie had an impressive start as he and the Redskins' starters accounted for the only touchdown in Washington's 7-6 victory.
Griffin's final stat line read: 4 for 6, 70 yards, one touchdown, no interceptions, no sacks.
She makes the call
Shannon Eastin has become the first woman to officiate an NFL game.
Eastin broke the NFL's on-field gender barrier, serving as the line judge for a seven-person crew working a preseason game between the Green Bay Packers and San Diego Chargers.
The 42-year-old from Tempe, Ariz., was dwarfed by the players as she lined up in front of San Diego's sideline and had a camera following nearly every move just before kickoff. She seemed at ease in the spotlight and had at least two players shake her hand.
Replacement officials were booed late in the first quarter of the Buffalo Bills' preseason opener against visiting Washington after muffing a call on a touchback.
Bills punter Brian Moorman hit a 49-yard punt, which Buffalo's Ruvell Martin downed at the Redskins' 4. Back judge Craig Burd, however, ruled it a touchback.
Fans began booing when the ball was placed at the 20 and they got louder when a replay was shown. Coach Chan Gailey challenged the play, which was reversed.