The U.S.-led NATO coalition said that no American or coalition troops were killed in the blasts. It confirmed that a number of troops were wounded but did not say how many, in accordance with coalition policy.
Shahidullah Shadid, a spokesman for the Wardak provincial governor, said one suicide bomber detonated a vest rigged with explosives outside a compound housing the district governor's office as well as local police and Afghan army headquarters. A second bomber driving a fuel tanker detonated his bomb on a road separating the compound from the base.
Shadid said the dead included eight civilians and four Afghan police.
Taliban spokesman Zabiullah Mujahid claimed responsibility for the attack, which he said was targeting the U.S. base.
Government officials said the first attacker blew himself up to try to eliminate the Afghan security force guarding the compound and clear the way for the truck to hit the base down the road from the governor's complex. The second bomber then blew up the fuel tanker as he was approaching the base. One of the town's main bazaars is also near the bomb site.
Officials said the second blast was far larger than the first.
"It was a very powerful explosion. It broke windows all over the area," said the provincial police chief, Gen. Abdul Qayum Bakizai. "Most of the injuries are from broken glass from the windows of homes and shops. It was so powerful we couldn't find much of the truck."
The governor's office said in a statement that 59 people were wounded - 2 NATO troops, 47 civilians, and 10 Afghan police officers.
Last year, the same base in Wardak was the target of a suicide bombing. That blast, which occurred on the anniversary of the Sept. 11 terrorist attacks against the United States, wounded 77 American soldiers and killed five Afghans.
In a separate incident Saturday, NATO said that two U.S. soldiers were killed in eastern Ghazni province. It did not provide any further information or details about the deaths. A total of 53 foreign troops were killed in Afghanistan in August.
The United States and other countries have begun drawing down their forces in Afghanistan as part of a strategy that aims to hand over security responsibility to the Afghans by the end of 2014, when nearly all foreign troops are set to leave the country. President Obama has pledged to remove 23,000 U.S. troops by the end of September, bringing the number of American forces down to 68,000.
There are 129,000 troops serving with the coalition, according to U.S. Maj. Gen. Joseph Reynes Jr., director of operations at the Allied Joint Forces Command in Brunssum, the Netherlands. He said the number will drop to 108,000 by the end of October and dip under 100,000 by the end of the year. The troops are to be replaced by Afghan army and police units, but many have questioned the effectiveness of an Afghan force that has high desertion rates and is often poorly disciplined..