The 6-foot, 220-pound Kane, who was used mostly at fullback and tight end last season, was one of La Salle's hardest workers in the offseason.
"We start lifting in January," the senior said. "I might have missed a few sessions, but not too many."
Kane, overcoming a slow start caused in part by O'Hara's regular blitzing, completed 12 of 20 throws for 183 yards.
"He's not only throwing the ball, but he's throwing it accurately," Explorers coach Drew Gordon said. "That's the reward for his stepping it up in the weight room."
Late in the first half, quick-footed sophomore Jimmy Herron, with a nifty sidestep of a Lions defensive back, turned Kane's right-side toss into a 33-yard score.
Kane and Herron, a receiver and direct-snap threat out of the wildcat formation, battled to replace two-year starter Matt Magarity under center.
Brett Gordon, La Salle's offensive coordinator and former star QB, "worked with me all summer in 7-on-7 passing leagues," Kane said. "That really helped a lot.
"Jimmy and I were both doing well in camp. Maybe it was just a matter of the coaches deciding to go with a senior over a sophomore."
Midway through the fourth quarter, after a 28-yard connection with Herron, Kane hooked up with wideout Sean Coleman, similarly fleet of foot, for a 26-yard TD that put the Explorers (3-0) in front, 31-6.
Through three games, Kane, of Horsham, has completed 41 of 63 passes for 672 yards and nine touchdowns.
"I think he's getting better very week," Coleman said. "He's playing awesome."
In track and field in the spring, Kane, who chose La Salle over runner-up St. Joseph's Prep, runs the 100-meter dash and throws the shot put. His best clocking in the 100 is 11.5 seconds.
"I wouldn't say I'm fast, but I'm decent once I get going," he said.
In the third quarter, Coleman, headed to Harvard for lacrosse, returned a Steve Weyler punt for a 78-yard TD. "I caught it, took a step in, and then bounced it to the outside," he said.
O'Hara's only score was Lamont Veal's 27-yard dash in the first quarter. The Lions (2-1) were held to 144 yards rushing and 41 passing.
"I don't question our kids' effort," O'Hara coach Danny Algeo said. "I thought our kids played hard. La Salle is really good."
Cardinal O'Hara 6 0 0 0 – 6
La Salle 3 14 7 14 – 38
LS: FG Ryan Winslow 30
CO: Lamont Veal 27 run (kick blocked)
LS: Jordan Meachum 4 run (Winslow kick)
LS: Jimmy Herron 33 pass from Chris Kane (Winslow kick)
LS: Sean Coleman 78 punt return (Winslow kick)
LS: Coleman 26 pass from Kane (Winslow kick)
LS: Ryan Coonahan 34 interception return (Matt Raczak kick)
Contact Rick O'Brien at 610-313-8019, firstname.lastname@example.org, or @ozoneinq on Twitter.