Williams gets support from fellow halfbacks Dan Knight and Ken Yoder and fullback Jarrett Reinhard. Kyle Wenger is a threat at wideout.
For the Titans, Adams, who has made quite the splash since arriving from Tamanend Middle School, has rushed 74 times for 937 yards and 18 TDs.
C.B. South (4-0 overall, 1-0 league) has won by an average of 35 points. Quarterback Jon Pileggi has hit on 42 of 52 throws for 557 yards and five TDs. His top targets are wideouts Paul Weeks and Cale Mosher.
To keep Adams from running wild for a fifth straight game, Souderton (3-1, 1-0) will rely heavily on nose guard Rick Young, tackle Connor Newlin, linebackers Reinhard and Colby Johnson, and strong safety Wenger.
C.B. South's defense has been anchored by tackle Tyler Paradysz, end Mike McDermott, linebacker John Mullin, strong safety Bobby Mallon, and cornerback Tommy Dibrino.
Souderton leads the head-to-head series, 4-0. The Big Red also won in 2009 (14-10 score) and 2008 (27-22).
We like the Titans, with continued rushing success, to get their first win over the Indians. Pick: C.B. South, 37-31.
Last week: 8-1. Overall: 33-9 (.786).
Germantown (2-2, 0-1 Public) at Frankford (2-2, 1-0), 3. For Frankford, Tim DiGiorgio and Denzel Turbeville are a solid pass-catch duo. Pick: Frankford, 27-13.
George Washington (4-0, 1-0 Public) at Central (3-0, 1-0), 3. Can Central keep linemen Justin Moody and Zaire Hollerway from making frequent visits to their backfield? Pick: GW, 28-6.
No. 4 Archbishop Wood (3-1) at Cardinal O'Hara (3-1), 7. It's the first night game at O'Hara's turf field. Pick: Wood, 35-20.
Cheltenham (3-1, 1-0 Suburban One American) at Plymouth Whitemarsh (3-1, 1-0), 7. PW's Corey Kelly and Terry Brown have combined for 989 rushing yards. Pick: PW, 23-7.
Springfield (D) (3-1, 3-0 Central) at No. 5 Garnet Valley (4-0, 3-0), 7. Can Springfield catch the Jaguars looking ahead to next week's clash with Ridley? Pick: GV, 33-14.
Kennett (3-1, 0-0 Ches-Mont American) at West Chester Rustin (3-1, 0-1), 7. The Golden Knights' run-heavy offense is paced by Adam Burke, Mike Pernsley, and Terry Loper. Pick: Rustin, 27-7.
No. 1 La Salle (4-0) vs. Archbishop Ryan (3-1), at Washington, 1. To gain the upset, Ryan will need a big effort from rusher Jeremiah Agrio. Pick: La Salle, 42-14.
No. 9 Coatesville (2-2, 0-1) at Unionville (3-1, 1-0), 2. Coatesville is focused on stopping Indians QB Tom Pancoast at the point of attack. Pick: Coatesville, 28-23.
No. 3 St. Joseph's Prep (3-0) vs. No. 8 Roman Catholic (2-1), at Northeast, 7. The Prep was idle last weekend; Roman played less than a half because of lightning. Pick: Prep, 30-7.
Contact Rick O'Brien at firstname.lastname@example.org, or @ozoneinq on Twitter.