Wayne and Luck delivered in a way Pagano wanted, with clutch plays.
Luck finished 31 of 55 for a career-high 362 yards, with two touchdowns and one interception. Wayne caught 13 passes for a career-high 212 yards and the game-winning score.
Things sure weren't easy for Indy, which had to dig itself out from a 21-3 halftime deficit. Luck threw an 8-yard TD pass to Dwayne Allen, then set up Adam Vinatieri for a 50-yard field goal to make it 21-13 midway through the third quarter.
The Colts were just getting started. Luck scored on a 3-yard run with 18 seconds left to get the Colts within 21-19. A few minutes later, the Colts took their first lead on Vinatieri's 28-yard field goal.
That's when Aaron Rodgers jump-started the Green Bay offense, throwing an 8-yard TD pass to James Jones to give Green Bay (2-3) a 27-22 lead with 4 minutes, 30 seconds left.
But Luck marched Indianapolis 80 yards in 13 plays, converting three third-down chances before hooking up with Wayne for the decisive score.
Colts 30, Packers 27
Green Bay 7 14 0 6 – 27
Indianapolis 0 3 16 11 – 30
First quarter
GB–Kuhn 2 run (Crosby kick), 2:07.
Second quarter
GB–Ja.Jones 6 pass from Rodgers (Crosby kick), 12:25.
Ind–FG Vinatieri 24, 6:21.
GB–Cobb 31 pass from Rodgers (Crosby kick), 4:21.
Third quarter
Ind–Allen 8 pass from Luck (Vinatieri kick), 11:06.
Ind–FG Vinatieri 50, 7:42.
Ind–Luck 3 run (pass failed), :18.
Fourth quarter
Ind–FG Vinatieri 28, 8:04.
GB–Ja.Jones 8 pass from Rodgers (pass failed), 4:30.
Ind–Wayne 4 pass from Luck (D.Brown run), :35.
A: 67,020.
GB Ind
First downs 21 28
Total Net Yards 356 464
Rushes-yards 23-141 30-119
Passing 215 345
Punt Returns 4-19 2-13
Kickoff Returns 3-95 0-0
Interceptions Ret. 1-0 1-0
Comp-Att-Int 21-33-1 31-55-1
Sacked-Yards Lost 5-28 4-17
Punts 7-45.1 5-44.6
Fumbles-Lost 0-0 1-0
Penalties-Yards 9-89 9-100
Time of Possession 24:44 35:16
INDIVIDUAL STATISTICS
Rushing: Green Bay, Rodgers 5-57, Green 9-55, Benson 7-20, Kuhn 2-9. Indianapolis, D.Brown 17-84, Luck 6-24, Ballard 6-11, Hilton 1-0.
Passing: Green Bay, Rodgers 21-33-1-243. Indianapolis, Luck 31-55-1-362.
Receiving: Green Bay, Cobb 4-82, Ja.Jones 4-46, Finley 3-11, Nelson 2-29, Benson 2-21, D.Williams 2-20, Driver 1-14, Green 1-8, Crabtree 1-6, Kuhn 1-6. Indianapolis, Wayne 13-212, Fleener 5-41, Allen 4-38, Hilton 3-37, Avery 3-22, D.Brown 2-8, Ballard 1-4.
Missed Field Goals: Green Bay, Crosby 52 (WR), 51 (WR). Indianapolis, Vinatieri 53 (WL).