It's also a rematch of last year's first-round matchup, won easily by Coatesville, 60-28.
"I don't think anyone is betting the house on us beating them," Spring-Ford coach Chad Brubaker said. "That's fine. When you're the underdog, you have nothing to lose."
Here is a closer look at the playoff.
Coaches. Coatesville's Matt Ortega is 33-13 (.717 winning percentage) in four seasons; Brubaker is 31-7 (.816) in three years in Royersford.
Rankings. Coatesville (11-2) is ranked No. 3 in Southeastern Pennsylvania by The Inquirer; Spring-Ford (12-2) is No. 6.
On a roll. After a 35-34 loss to Downingtown East in Week 4, Coatesville has won nine straight games by a combined score of 384-116.
Balanced attack. In last week's 35-24 triumph at Pennridge, the Rams totaled 201 yards on the ground and 193 through the air.
Speedy bunch. The Red Raiders have a trio of burners: running back Daquan Worley (167 carries, 1,278 yards, 15 TDs) and wideouts Chris Jones (55 catches, 1,286 yards, 19 TDs) and Dre Boggs (27, 704, 11).
Experienced QB. Spring-Ford's Hank Coyne, a third-year starter, has completed 132 of 234 passes for 1,790 yards and 24 touchdowns.
Solid counterpart. Coatesville's Emmitt Hunt, a first-year QB, has connected on 117 of 183 throws for an area-best 2,576 yards and 36 TDs.
One-two punch. Spring-Ford running backs Jarred Jones (108 carries for 940 yards, 10 TDs) and Yousef Lundi (145 for 1,039, 16) have combined for 1,979 yards and 26 touchdowns.
Explosive. In last week's 63-28 romp over Neshaminy, the Red Raiders totaled 202 yards rushing on 23 attempts. Hunt went 12 for 14 for 313 yards and four TDs.
Up front. For the Rams, a defensive line that must put heat on Hunt features end Zameer McDowell and R.J. Sheldon, and tackles Mason Romano and Robby Varner.
Rugged group. Coatesville's defense is headed by nose guard Mike Boykin, tackle Dylan Morgan, and linebackers Tyler Burke and Steve Pawling.
Intriguing matchup. Keep an eye on the head-to-head tussle between Boykin, a standout wrestler at 220 pounds, and Spring-Ford guards Zach Dorsey and Josh Boyer.
Analysis. A lot will depend on the Rams' success at pressuring Hunt. We expect the Red Raiders line, with junior tackle Colin Raysor as the anchor, to respond well to the challenge.
Pick. Coatesville, 38-21.
Contact Rick O'Brien at firstname.lastname@example.org, or @ozoneinq on Twitter. Read his blog, "The O'Zone," at www.philly.com/ozone