Being ready to play was something O'Brien wasn't the last two seasons in Boston.
O'Brien was sidelined last season as a medical redshirt after undergoing his second surgery on his left foot. He originally broke his foot during the 2010-11 season. He is eligible to play immediately at Temple due to taking graduate courses not offered at BU.
"Sitting back and not being a part of things is hard," said O'Brien, who averaged career highs of 13.8 points and 6.4 rebounds as a sophomore at BU. "It's a hard pill to swallow.
"I think now that I'm healthy, you've got to kind of not take things for granted. So being a senior and having a number of games left in my college career, I'm just going to go out and give it everything I have."
O'Brien's best game at Temple came during an 80-75 victory over Delaware on Nov. 25. He made three of five three-point attempts en route to a season-high 13 points. The 23-year-old also finished with three rebounds, an assist and a blocked shot in 18 minutes.
The Owls hope he will be able to duplicate that performance against the Wildcats.
Villanova (4-3, 0-1 Big 5) has won the last six meetings with Temple at the Pavilion. Temple's last victory there was a 70-57 decision on Nov. 29, 1990.
"I've heard a lot about the Big 5 and the rivalries and what that means for each school and for the city," O'Brien said. "So I've been tutored on that."
Temple at Villanova
Wednesday at the Pavilion, 9 p.m.
TV/Radio: ESPN2; WPHT-AM (1210), WIP-AM (610)
Records: Temple, 5-0, 0-0 Big 5; Villanova, 4-3, 0-1.
Coaches: Temple, Fran Dunphy, seventh season, 139-65; Villanova, Jay Wright, 12th season, 241-133.
Series: Villanova leads, 43-41, but Temple took a 78-67 victory last season at the Liacouras Center.
Probable starters
Temple
32 Rahlir Hollis-Jefferson F 6-6 Sr. 9 ppg. 5.6 rpg.
3 Anthony Lee F 6-9 Soph. 10.4 ppg. 7.2 rpg.
33 Scootie Randall G/F 6-6 Sr. 15.8 ppg 7.2 rpg.
1 Khalif Wyatt G 6-4 Sr. 15.6 ppg. 5 apg.
2 Will Cummings G 6-2 Soph. 5.4 ppg. 1.8 apg.
Villanova
13 Mouphtaou Yarou F 6-10 Sr. 9 ppg. 5.6 rpg.
25 Maurice Sutton F/C 6-11 Sr. 5.9 ppg. 3.7 rpg.
32 James Bell G/F 6-5 Jr. 10.7 ppg. 4.7 rpg.
15 Ryan Arcidiacono G 6-3 Fr. 12.9 ppg. 3.3 rpg.
4 Darrun Hilliard G 6-6 Soph. 10.3 ppg. 2.7 rpg.
- Keith Pompey
Contact Keith Pompey at kpompey@phillynews.com.