McCollum broke his left foot last week in a game against Virginia Commonwealth. He underwent what the school deemed "successful surgery" on Tuesday.
The estimated recovery time is 8 to 10 weeks, but the school warned that would depend on the healing process. The timeline could make him available in early March.
At the time of his injury, McCollum was leading the country in scoring (25.7 points). Lehigh (10-4) hosts Holy Cross to open Patriot League play on Saturday.
McCollum is considered a potential first-round pick in the NBA draft, and has averaged 21.3 points over his career at Lehigh. On March 16 of last year, McCollum scored 30 points as Lehigh, a No. 15 seed, defeated Duke, 75-70.
Jack Taylor, who set the NCAA scoring record with 138 points for Grinnell College in a game in November, is out for the season after breaking his wrist Wednesday in a 119-117 win over Cornell College. He likely will have surgery within a week and be out 2 to 3 months.
In games Thursday *
At Oregon, E.J. Singler had 14 points and the Ducks (13-2, 2-0 Pac-12) upset No. 4 Arizona, 70-66. The Wildcats (14-1, 2-1) were led by Mark Lyons' 21 points.
* At Iowa, Branden Dawson scored a career-high 17 points and No. 22 Michigan State (13-3, 2-1 Big Ten) won, 62-59.
* At North Carolina, Kenny Kadji scored 18 points and Miami (11-3, 2-0 Atlantic Coast Conference) beat the Tar Heels, 68-59. James Michael McAdoo had 14 points for North Carolina (10-5, 0-2).