The Hoyas (20-4, 10-3) shot 63 percent and scored a season-high in points, handling with relative ease a possible trap game ahead of Saturday's much-anticipated final Big East visit to No. 8 Syracuse. Georgetown, Syracuse and Marquette sit in a three-way tie atop the conference.
Brandon Young scored 16 points to lead the Blue Demons (11-15, 2-11), who have lost 12 in a row to Georgetown and 40 straight to Top 25 teams.
DePaul was coming off of a win over Rutgers on Saturday and was hoping to win back-to-back Big East games for the first time in 5 years.
The Blue Demons hung with the Hoyas for about 14 minutes, thanks mainly to offensive rebounds and some uncharacteristic defensive lapses by Georgetown. Statistical oddities from the first half: DePaul had an 11-0 advantage in second-chance points, while Georgetown dominated 12-0 in points off turnovers.
In other games *
At Syracuse, James Southerland scored 20 points, Michael Carter-Williams had 15 points and 12 assists, and the No. 8 Syracuse (22-4, 10-3 Big East) posted an 84-59 win over Providence (14-12, 6-8).
* At Oklahoma State, Naadir Tharpe's jumper with 20 seconds left in the second overtime stood up as the game-winner as No. 9 Kansas (21-4, 9-3 Big 12) earned a 68-67 win over the No. 14 Cowboys (19-6, 9-4). Tharpe had gone 1-for-9 before hitting the winner.
* At Ohio State, Deshaun Thomas overcame a slow start to score 19 points and No. 18 Ohio State (19-7, 9-5 Big Ten) used a 16-0 second-half run in its 71-45 win over Minnesota (18-9, 6-8).
* At Northwestern, No. 19 Wisconsin (19-8, 10-4 Big Ten) held the Wildcats (13-14, 4-10) to 29 percent shooting in the Badgers' 69-41 victory.
* At Memphis, Adonis Thomas had 22 points as the No. 21 Tigers (23-3, 12-0 Conference USA) posted their 17th straight win, 81-74 over Houston (15-10, 4-8).
Former Texas forward Gary Johnson, 24, is expected to make a full recovery after fracturing his skull in a collision with an opponent during a second-division Israeli game.