Speller, who didn't score at all in last year's state final, scored 10 of her points in the game's crucial third quarter.
"This team probably had a lot to prove, and they played like it," Archbishop Wood coach Jim Ricci said.
Lancaster Catholic advances to the quarterfinals where it will face Blackhawk on Saturday.
Villa Maria 44, Holy Redeemer 40 - Villa Maria beat Holy Redeemer at Bethlehem Freedom in a contest that coach Kathy McCartney said was "close throughout the whole game."
Senior guard Lisa Mirarchi led Villa Maria with 17 points and hit two free throws to close out the four-point win with six seconds left. As a team, Villa Maria shot 5 for 8 from the line in the final two minutes.
Villa Maria led by one heading into the fourth quarter and held on behind Mirarchi, who shot 4 for 5 in the final quarter.
Junior forward Jackie Carlin scored 14 points and had 11 rebounds for Villa Maria, which advances to play Scranton Prep in the quarterfinals Saturday.
Lourdes College 57, Girard College 42 - Lourdes College won in a Class A second-round game at Reading. Rachel Schultz led Lourdes with 19 points. Sarah Getchey scored 15 points for Lourdes and Nikki Komara added 10 points.
Lourdes College advances to the quarterfinals, where it will face Southern Fulton on Saturday. Southern Fulton beat Halifax, 73-34, in the second round.
Steelton-Highspire 74, Jenkintown 39 - In other Class A second-round play, two-time defending state champion Steelton-Highspire defeated Jenkintown. Senior guard Malia DeFreitis led Steelton-Highspire with 27 points. Steelton-Highspire advances to face Tri Valley, which beat Old Forge, 68-44, in the quarterfinals on Saturday.
Contact Joey Cranney at JCranney@philly.com. Follow on Twitter @joey_cranney.