Oregon advanced to play fourth-seeded St Louis on Saturday.
Smart went into the game with the hype of a top NBA prospect but was held to 14 points on 5 for 13 shooting, a disappointing finish to a stellar season for the Cowboys (24-9).
St. Louis 64, New Mexico State 64 - Dwayne Evans scored 24 points, Cody Ellis added 12 points, and the fourth-seeded Billikens (28-6) overwhelmed the Aggies (24-11) in San Jose.
Playing with a heavy heart since Rick Majerus died in December, St. Louis reached another mark in March for its late coach. The Billikens eclipsed the 1988-89 team's school record of 27 victories.
Evans shot 11 of 16 from the floor and finished a point shy of his career best.
Colorado State 84, Missouri 72 - Dorian Green scored 17 of his 26 points in the first half, and eighth-seeded Colorado State (26-8) used good shooting to run away from No. 9 Missouri (23-11).
Louisville 79, North Carolina A&T 48 - Russ Smith scored 23 points and set a Louisville NCAA tournament record with a career-high eight steals, and Peyton Siva had eight assists as the Cardinals demolished North Carolina A&T in Lexington, Ky.
Louisville finished with a season-high 20 steals as it forced the Aggies (20-17) into 27 turnovers. It was the 11th straight win for the Cardinals (30-5).
Michigan State 65, Valparaiso 54 - Derrick Nix had 23 points and a career-high 15 rebounds to help power the third-seeded Spartans (26-8) past 14th-seeded Valparaiso (26-8) in Auburn Hills, Mich.
The Spartans went on a 26-5 run in the first half to take control.
Michigan State will play Memphis on Saturday, when Spartans coach Tom Izzo will be shooting for a spot in the round of 16 for the fifth time in six years.
Memphis 54, St. Mary's 52 - Matthew Dellavedova's three-pointer from the right wing sailed long as time expired, allowing the sixth-seeded Tigers (31-4) to hold on over the Gaels (28-7) in Auburn Hills.