Indiana (28-6) is led by player of the year candidates Cody Zeller and Victor Oladipo, though coach Tom Crean has a half-dozen options after those two studs.
Against JMU, point guard Yogi Ferrell had 16 points and Will Sheehey came off the bench to add 15.
The Hoosiers led, 43-22, at the half. They outscored the Dukes 13-4 to start the second half and led by as many as 33 - 68-35 - after Sheehey dunked with 8:17 left in the game.
Zeller and Oladipo finished with 11 points each and Jordan Hulls chipped in 10.
Andre Nation led the Dukes (21-15) with 24 points. Ron Curry of Paul VI in Haddon Township, N.J., and Taylor Bessick of Frankford High, scored two points each.
Indiana and Temple haven't played each another since 2004 when John Chaney was leading the Owls and Mike Davis was in charge of the Hoosiers. The Owls hold a 5-4 series lead, for whatever that's worth.
Temple is 0-8 against No. 1 seeds since 1985. All of those games were while Chaney as coach, with the last coming in 2001 when the Owls lost to Michigan State in the Elite Eight.
James Madison coach Matt Brady, a former assistant at Saint Joseph's, was asked if he had any pointers for Dunphy.
"Fran doesn't need my advice," Brady chuckled. "Fran's teams have always had the ability to manage the tempo . . . Fran's teams [always] compete, and they played more teams like this than my group has."