Holiday scored on back-to-back baskets - the second of which was a powerful one-handed dunk down the middle of the lane that gave the Sixers a 91-84 lead with 4 minutes, 8 seconds left in the game.
Later, his jumper with 1:02 left in the game preceded a breakaway dunk by Damien Wilkins that gave the Sixers a 97-90 lead with slightly more than 30 seconds left.
South Jersey native Michael Kidd-Gilchrist led the Bobcats with 21 points. Gerald Henderson, formerly of Episcopal Academy, added 19.
One year after the Bobcats established the worst winning percentage in league history (.106), they are, again, the worst team in the league (17-56).
This, however, did not prevent the Bobcats from jumping out to a 30-17 lead in the first quarter.
Down by nine points at the start of the second quarter, the Sixers, behind 11 points from Thaddeus Young, outscored the Bobcats 27-15 in the quarter to lead by 49-46 at halftime.
The Sixers are 51/2 games behind the Milwaukee Bucks for the final spot in the Eastern Conference playoffs.
Before the game, Sixers coach Doug Collins talked at length about what he wants to see from some of the younger players such as Lavoy Allen and Arnett Moultrie.
Neither player distinguished himself on Saturday, though. Moultrie did not appear in the game. Allen scored just one point and grabbed one rebound in 14 minutes.
Allen, in his second season, has had his moments this season - he grabbed 22 rebounds earlier in a victory over the Bobcats, but Collins made it clear that he expected more from Allen, who came into the game averaging 6.1 points and 5.2 rebounds.
"He has been better," Collins said of Allen, whom the Sixers rewarded with a two-year, $6.1 million deal after his rookie season. "But I think I expected more from Lavoy all year because of the way he finished [last] season. Lavoy can do it. With Lavoy it's all about the motor and getting that thing moving. I've talked to Arnett about that too."
More than anything, Collins wants his big men to run the floor even when they don't know whether or not they will touch the ball. Collins pointed out Denver Nuggets second-year forward Kenneth Faried. Taken in the same draft as Allen, Faried has started all season for the Nuggets. Through 74 games Faried, who is 6-foot-8 - smaller than both Allen (6-9) and Moultrie (6-10) - was averaging 11.7 points and 9.2 rebounds on a team that is peaking for a playoff run.
"He has the mind-set that he will always sprint the floor," Collins said. "I want to see our guys develop that."
Contact John N. Mitchell at firstname.lastname@example.org. Follow @JmitchInquirer on Twitter.