Shelby Kenny scored the game-winner off the draw 13 seconds later to send the 18th-seeded Cardinals to the next round. North Penn was the 16th seed.
McAneney scored four goals, making the most of her new role. The Cardinals played with several girls in unfamiliar positions.
"For us to come and win this first-round game with our backs against the wall, that's really special," Upper Dublin coach Dee Cross said.
Sophomore Sarah Gallagher made 15 saves.
Radnor 17, Upper Merion 2 - Eight players scored as the top seed rolled past visiting Upper Merion, the 32d seed. Shannon Quinn, Sara Curley, Brooke Pancoast, and Taylor Quinn each scored three times.
Springfield (D) 19, Council Rock South 7 - Ali Gormley, Alex Poplawski, and Emily Santana scored five goals apiece to lead the host third seed past No. 30 Council Rock South.
Harriton 19, Central Bucks East 6 - Caleigh Foust erupted for eight goals to lift the fourth-seeded Bears past visiting Central Bucks East, the 28th seed.
Boyertown 15, Unionville 5 - Kait DeHaven scored six goals, and Rachel Engler added four to lead the seventh-seeded Bears past visiting No. 26 Unionville.
W.C. Henderson 15, Wissahickon 3 - Katie O'Donnell scored seven times, and the 10th-seeded Warriors defeated visiting Wissahickon, the 23d seed.
Mount St. Joseph 20, Central Bucks West 10 - Olivia Gannon fired in seven goals, and Emily Ehret and MK Maloney each scored three for the 11th-seeded Magic in a win over the visiting 22d seed.
Merion Mercy 14, Downingtown West 10 - Caroline Corzel and Olivia Nostrant carried the offense for the 12th-seeded Golden Bears in a home win over No. 21 Downingtown West. Nostrant, a junior, scored six goals. Corzel, a sophomore, netted one goal and assisted on five others. Lauren Thomas made nine saves.
Second-seeded Germantown Friends will go for its first Friends School League championship in school history after beating visiting Abington Friends, 6-5, in the semifinals. Fighting to stay alive with an 0-2 count, Lizzie Becker doubled to score the winning run in the bottom of the seventh. Erica Heinz went 2 for 3 with a double, an RBI, and a run scored.
In the other league semifinal, fourth-seeded Friends' Central won at No. 1 Friends Select, 3-1. Brianna Powell went 2 for 3 with a double and drove in two runs.
Inter-Ac. Taylor Lord and Emily Speakman sparked the offense for Agnes Irwin, which gave visiting Penn Charter its first league loss of the season, 10-0. Lord and Speakman both went 2 for 3 and knocked in two runs. Penn Charter had clinched the league title on Monday.
Contact Tim McManus at email@example.com.