There are position battles throughout the defense, which has been reworked from a 4-3 to a 3-4 and includes major personnel changes. But barring injury, Cox will start on the end in the three-man defensive line and Kendricks will start at inside linebacker.
Both will be 22 on opening day, the team's youngest expected starters on offense and defense. They're both younger than first-round pick Lane Johnson.
Both have noticed a marked difference between their first and second seasons. Kendricks remembered the veterans telling him how much easier the second season is compared with the first, and he is "astounded" by how accurate they were.
"The speed of the game has completely slowed down to the point that I'm thinking a whole lot more faster, seeing things a whole lot more clear," Kendricks said. "Just the general understanding of the game, of the way the NFL game works."
Cox, who takes pride in being a quick learner, said he was just trying to acclimate to the rhythm of the NFL last season. This year, he said he knows what to expect.
His best production came after he entered the starting lineup for his final seven games of the season, when he recorded 41/2 of his 51/2 sacks. That was an encouraging sign, but Cox expects more.
"I never say I'm that guy - I always do that to humble myself," Cox said. "I never think I've arrived. That's when you stop focusing on the main things."
The Eagles' scheme change is not dramatic for either player. Kendricks played in the 3-4 during two of his seasons at California, so he's familiar with the principles of the defense.
The Eagles moved Kendricks between outside linebacker spots last season, but he is purely an inside linebacker in the new defense.
Chip Kelly coached against Kendricks in college and had a glimpse of his skills.
"Chip hated me, probably," Kendricks said. "I killed him, straight up."
Kendricks pointed to the game against Oregon in his junior year that included 10 tackles, 11/2 tackles for loss, and a sack.
"LaMichael James didn't have anything against me," Kendricks said of the former Oregon running back, who had a season-low 3.1 yards per carry in the game against Cal in 2010. Kelly reminded Kendricks of that game when Kelly was hired by the Eagles.
When the idea of switching to a 3-4 defense first came about after Kelly's hire, general manager Howie Roseman insisted that Cox could play in a changed scheme. Even though the Eagles liked Cox as an ideal fit in Jim Washburn's defense last year, teams viewed him as a potential 3-4 defensive end in the 2012 draft and Roseman said in February that Cox "can really play in any scheme."
That's one of the reasons there should be optimism about Cox and Kendricks even amid understandable skepticism elsewhere. There are other players on the defense who have body types or skill sets that might make the conversion a challenge. But the top two picks from last season are natural fits.
"We talk about how we came in as the top two draft picks last year, and they were expecting us to learn the defense and come in and play," Cox said. "Of course, long-term, we want it to stay that way."
For an online only position-by-position look at the Eagles roster, go to inquirer.com/sports/eagles
Contact Zach Berman at firstname.lastname@example.org. Follow on Twitter @ZBerm.