Mayweather's next opponent is guaranteed a handsome payday, and Hopkins would surely like a piece. But Hopkins also believes he presents the best opposition for the pound-for-pound king.
Young fighters, he said, would be too overmatched against Mayweather's chess-like strategy.
"They don't have the IQ. They don't have the skills which pay the bills," said Hopkins. "They don't have the whole makeup that's needed to beat a mind like that."
Juniata Park's Danny Garcia, who scored a unanimous decision this month on the undercard of Mayweather's last fight, is a favorite to meet Mayweather.
Hopkins said he would rather have the 25-year-old Garcia, his protégé, fight Mayweather as long as the public bought in.
Mayweather's visually lopsided majority decision over Canelo Alvarez makes it increasingly difficult to find Mayweather a suitable opponent.
The promoters have to find someone who customers believe has a chance to top Mayweather. Not just a foe, Hopkins said, who might give Mayweather a bloody nose.
Hopkins was ringside, wearing his promoter hat, earlier this month in Las Vegas as he sat between Golden Boy Promotions CEO Richard Schaefer and "the billionaire CBS guy."
He was energized during Garcia's win over Lucas Matthysse and "quiet as a church mouse" during Mayweather's fight. Hopkins needed just three rounds to know that Alvarez did not have a chance.
That's when a "very powerful person" asked Hopkins if he could lose nearly 15 pounds to go from light heavyweight to middleweight, where Hopkins once ruled, for a chance at Mayweather.
Mayweather's last pay-per-view grossed a record $150 million, and now they need to try to match it.
"The only person that can beat a master chess player is the master chess player himself," said Hopkins.
Contact Matt Breen at firstname.lastname@example.org. Follow @matt_breen on Twitter.