West Deptford has won 25 in a row and features a balanced running attack with seniors Gerald Owens, a Michigan State recruit; Joe Diaco; Devin Bates; and Isaiah Worthy.
Sterling is coming off a 13-0 win over Haddonfield. The Silver Knights have dangerous backs in senior Zyaire Gibson (seven touchdowns) and junior Davon Tucker.
Pick: West Deptford, 27-13.
No. 1 Holy Spirit (4-0) at No. 8 Millville (3-1). There will be plenty of atmosphere at historic Wheaton Field when the top-ranked, senior-laden Spartans arrive in the center of Millville.
Holy Spirit's stingy defense is led by tackle Ray Ellis, linebackers Jeff Steeb and Mike Mooney, and cornerbacks Franco Rifici and A.J. Dawson. Quarterback T.J. Anderson directs a triple-option attack.
Millville is led by senior two-way tackle Antoine White, a Penn State recruit, as well as explosive junior running back Rob Ennis (nine touchdowns) and senior all-purpose threat Ryquell Armstead.
Pick: Holy Spirit, 20-14.
No. 13 Clearview (4-1) at No. 2 Eastern (5-0). Vikings senior Tom Flacco needs 210 yards to become just the second quarterback in South Jersey history with 6,000 passing yards.
Eastern senior WR Keshawn Segers leads South Jersey with 582 receiving yards, and senior linebacker Kingsley Ayeni sparks a defense that shut out Williamstown, 14-0, last week.
Clearview is coming off a dramatic 15-14 win over Shawnee. The Pioneers have been getting strong work from senior running back George Kerasinis and received a big boost last week from the eligibility of junior tight end Sterling Sheffield, who caught five passes for 82 yards against Shawnee.
Pick: Eastern, 24-14.
No. 25 Pennsville (4-0) at No. 21 Woodstown (4-0). Something has to give when the visiting Eagles' potent offense meets the Wolverines' dominant defense.
Pennsville quarterback Dylan Cummings lead South Jersey with 18 touchdown passes. Linebackers Levi Simpkins and Mario Catalano, strong safety Dillon Hill, and cornerback Tariq Thomas have been standouts for the Woodstown defense.
Pick: Woodstown, 27-20.