C.J. Spiller, RB, Bills at Steelers. With E.J. Manuel back under center, Pittsburgh can't afford to stack the line against Buffalo's dual-threat rushers.
Mike James, RB, Buccaneers vs. Dolphins. The rookie has proved to be a worthy stand-in for Doug Martin. In fact, I submit James' performance against the Seahawks last week was more impressive than anything we saw from Martin this year.
Golden Tate, WR, Seahawks at Falcons. With Sidney Rice out and Percy Harvin still working himself into game shape, Tate has only Doug Baldwin to compete with for Russell Wilson's affections.
Hakeem Nicks, WR, Giants vs. Raiders. You saw what Riley Cooper did against Oakland's secondary last week, right? As inconsistent as Nicks has been this season, you still have to love his chances on Sunday.
More thumbs up (excluding the no-brainers): QBs Matthew Stafford, Jay Cutler, Philip Rivers, Ben Roethlisberger; RBs Reggie Bush, Chris Johnson, DeMarco Murray, Knowshon Moreno, Eddie Lacy, Zac Stacy, Pierre Thomas; WRs Keenan Allen, Lance Moore, Alshon Jeffery, DeSean Jackson, Antonio Brown, T.Y. Hilton, Torrey Smith, Stevie Johnson, Denarius Moore, Mike Wallace, Larry Fitzgerald.
Roll 'em back
Matt Ryan, QB, Falcons vs. Seahawks. Aside from one strong outing against the Bucs in Week 7, Ryan has been a disaster without his starting wideouts on the field. He's thrown seven interceptions and only two TDs in his last two outings.
Ben Tate, RB, Texans at Cardinals. After adding a back injury to his hamstring woes, Arian Foster's prospects appear dim for this weekend's tilt. That would normally be good news for Tate, but he remains a very risky bet as he's fighting through four cracked ribs.
Rashad Jennings, RB, Raiders at Giants. Though Jennings performed admirably last week after Darren McFadden suffered yet another hamstring injury, he's hard to trust against a New York defense that has stifled LeSean McCoy and Adrian Peterson over its last two games.
Jarrett Boykin, WR, Packers vs. Eagles. His value took a big hit when James Jones returned to the field. Then disaster struck with Aaron Rodgers' injury, reducing the Packers' passing attack to average, at best.
Anquan Boldin, WR, 49ers vs. Panthers. Boldin is one of those guys who produce when you least expect it. That said, he's becoming an afterthought in the 49ers' passing game, with Vernon Davis getting all the love.
More thumbs down: QBs Colin Kaepernick, Carson Palmer, Joe Flacco, Seneca Wallace; RBs Trent Richardson, DeAngelo Williams, BenJarvus Green-Ellis, Andre Brown; WRs Marques Colston, Hugh Douglas, Tim Wright, Marlon Brown.
Don't be the bonehead who . . . benches Jordy Nelson just because Rodgers won't be under center. While his visits to the end zone will surely dwindle, Seneca Wallace has little choice but to keep looking Nelson's way. It helps that the Packers face one of the league's worst pass defenses at home this week.