Democratic U.S. Sens. Bob Casey, of Pennsylvania, and Michael Bennet, of Colorado, spoke during cocktail hour to introduce the president, who poked fun at himself over the troubled Obamacare rollout and described his plans for the rest of his second term.
"As president of the United States, everybody says, well, the most powerful office on Earth is yours, and yet almost everything I do depends on the hard work and cooperation of members of Congress. And that's hard to find sometimes in this political environment," Obama said, according to a White House transcript. "I've got three years left in this office. In addition to rebuilding this website [laughter from crowd], I want to make sure we're rebuilding our infrastructure all across the country. I want to make sure we're investing in early childhood education."
During a Q&A, Obama fielded questions about climate change, energy policy and the rancorous nature of political discourse, said someone who attended the event.
The crowd included real-estate developer Israel Roizman, Lehman Brothers heir Peter Buttenweiser, US Airways executive Stephen Johnson and attorney Matt Casey, the source said.
Trying to preserve the Democrats' thin majority in the Senate in next year's midterm elections, the president has been on a whirlwind fundraising tour in recent days, with stops in Dallas and Miami.
Twenty Democratic seats are up for election in the 2014 cycle, while Republicans are playing defense in only 13 states. Pennsylvania's next Senate bout isn't until 2016, when Republican Pat Toomey is expected to seek a second term.
Mayor Nutter, who at times has been rumored to be eyeing that race, greeted Obama at the airport and joined him at the event, but did not make a donation.
"You've got an outstanding mayor here in Philadelphia, Mr. Michael Nutter," Obama told the crowd. "We're very, very proud of him."
Former U.S. Rep. Joe Sestak, a Democrat who is expected to run for the seat in 2016, did not attend.
Cohen, who served as chief of staff to former Mayor Ed Rendell, has now hosted four fundraisers with Obama at his home and earned maybe the biggest shout-out of the night.
"The only thing I haven't done in this house is have seder dinner," Obama said. "But [Cohen and his wife] have just been such great friends, and I'm so grateful to them, and I really appreciate it."
On Twitter: @SeanWalshDN