Some critics will point out that the Rockets (5-4) played without all-star shooting guard James Harden (bruised left foot).
Although he might have made a difference, Anderson and Wroten were this game's biggest difference makers. Anderson might have had some added motivation.
The 6-foot-6 shooting guard scored a career-high 36 points against the team that waived in him in July. It was the most points by a Sixer since Willie Green had 37 points against the Toronto Raptors on April 18, 2007.
Anderson made 6 of 8 three-pointers Wednesday after making just 9 of 27 during the Sixers' first eight games.
"I was more of a shooter in college [at Oklahoma State] and changed it around when I got here," Anderson said. "I was inconsistent shooting threes with guys running me off. I had to change and adjust. It just happened."
Wroten also had to adjust his game.
Usually the sixth man, he started at point guard in place of Michael Carter-Williams, who missed the game with a bruised left foot.
Wroten responded with 18 points, 11 assists, and 10 rebounds to put him in the record books: He became the first player in NBA history to post a triple-double in his first start.
"James Anderson and Tony played exactly like we thought," Brown said with a laugh.
The two players teamed up on the play that forced overtime.
With the Sixers trailing, 106-103, Wroten drove underneath the basket and leaped to throw a high pass to Anderson. After coming down with the ball, Anderson launched a three-pointer that knotted the score with 6.9 seconds left.
"Tony already had told me he was going to look for me and I was kind of in the wrong spot," Anderson said. "But somehow he still found me and I was fortunate enough to get a shot off and fortunate it went in."
Spencer Hawes had a putback dunk to give the Sixers a 115-114 advantage with 34 seconds remaining in overtime. The Sixers went on to build a five-point cushion before Jeremy Lin's three-pointer closed the gap to 119-117 with eight seconds left.
But Thaddeus Young and Evan Turner (23 points) went on to sink four foul shots to secure the victory.
Lin made nine three-pointers to lead the Rockets with a season-high 34 points. Dwight Howard added 23 points, 15 rebounds, 6 assists, 6 blocked shots, and 2 steals.