It was the Sixers' seventh loss in eight games.
Holiday was a pest, forcing the rookie to make poor passes and walking him into double-team traps in hopes of easy turnovers.
In the second quarter, Holiday pushed one of the Sixers 18 turnovers up-court to Chester native Tyreke Evans, who tossed an easy alley-oop to Anthony Davis. A few minutes later, another Carter-Williams turnover set Davis on a fastbreak which he punctuated with a layup.
Carter-Williams committed four of his turnovers in the first half.
"One thing that I want someone to tell him is that if he gets a mid-range [game] he'll be killer," Holiday said. "He can shoot the three and get to the rack, but if he gets a mid-range, the man is going to be nice."
Carter-Williams missed the Sixers' loss at New Orleans earlier this season and Pelicans head coach Monty Williams said he warned Holiday that he would need to be aggressive with the hot-handed rookie.
Holiday, traded to New Orleans in June, dropped in 20 points and dished out 13 assists.
"I didn't get too many boos," said Holiday. "It's a little surprising, but it's definitely a good thing."
Holiday seemed to be comfortable in a more traditional point-guard role, as he played a lot from the top of the key but still was able to create open space for himself.
He effectively set up Eric Gordon for an array of jumpers as the guard scored a game-high 26 points.
The New Orleans coach also said he needed to find more playing time for Evans.
Traded for in the offseason, Evans is still adjusting to his non-starting role. He played 35 minutes on Friday and scored 16 points.
After Friday morning's shoot-around, Spencer Hawes said it was the first time that his left knee had felt fine since he was sidelined last week.
He remained a game-time decision, but was cleared after the team warmed up. He finished with 12 points, but had trouble limiting Davis. The second-year center grabbed 10 rebounds and scored 22 points.
"We're going to take some hits and it's going to be a test," said coach Brett Brown. "It's going to be a test for the city, it's going to be a test for the team. We have forecasted this from day one and it's my job to keep everyone focused in relation to what we're trying to accomplish here."
The Sixers also welcomed back Tony Wroten, who showed no signs of his lower back-strain as he split a double team in the first quarter for a driving one-hand slam.
He came off the bench to score seven of his team-high 24 points in the opening quarter.
Wroten played the early minutes of the fourth quarter, before Carter-Williams and three other starters reentered as the Sixers looked for one last push from a double-digit deficit.
And from the Pelicans bench came Holiday to play the foil.