The Golden Eagles (13-2) outrebounded Drexel, 52-34, including a 22-6 advantage on the offensive end, as they outscored the taller Dragons, 28-12, in the paint.
The Dragons struggled shooting from the floor (38 percent) and made only five of 17 free throws (29 percent).
Trailing by only 31-28 at halftime, Drexel managed only six points over the first 13 minutes, 17 seconds of the second half, as USM ran away to a 60-34 lead with 6:43 to play.
"With 6 minutes to go, my assistant said, 'Hey, you know we've got six points, right?' " Flint said. "But it wasn't a surprise [because] we played that way."
USM scored the first 10 points of the second half to break open a tight game as the Dragons (8-5) lost for the third time in their last four games and dropped back-to-back games for the first time this season.
The Golden Eagles won their fourth game in a row and improved to 5-0 at home.
Sophomore forward Tavan Allen led the Dragons with 15 points, while senor guard Chris Fouch added 13 points.
USM guard Aaron Brown, a Temple transfer, led four Golden Eagles in double-figure scoring with 11 points, while forwards Michael Craig and Jeremiah Eason and guard Jerrold Brooks added 10 apiece.