"I have no idea about the team that I just saw the last 2 nights," Sixers coach Brett Brown said . "The fatigue must have played a far greater factor than I anticipated. It's one of the great challenges of the NBA."
Things got out of hand quickly. Miles hit five of his three-pointers in the first quarter, setting up the Cavaliers with a 16-point lead going into the second. The lead was pushed to 23 at the break as the Sixers' shooting percentage plummeted to under 39 percent.
"You most definitely give him [Miles] credit. You have to be aware of where he is every second," Brown said. "He's an elite shooter and we just didn't get the job done on him defensively."
The Sixers missed their first five shots of the third quarter, and the Cavaliers stayed hot, never allowing the Sixers to put a dent into their lead. From there, the game was on cruise control, as the Cavaliers extended their lead to as many as 31 points.
The Sixers shot 39.5 percent from the floor, extending their record to 2-16 when they shoot under 45 percent.
The bright spot of the night was guard Michael Carter-Williams, who set a career high with 33 points and never gave up as the game got out of hand.
"He stayed strong as a leader, he got the group together," Brown said. "He continued to persevere, trying to make sure that we could hold our head high leaving this gym."
Other than Carter-Williams, few Sixers had much left in the tank. Guard James Anderson had 15 points, guard Elliot Williams scored 12 and forward Brandon Davies added 11.
Forward Thaddeus Young, the reigning Eastern Conference Player of the Week, had scored at least 17 points in each of the past eight games entering last night's matchup, but he went 0-for-7 from the field and finished scoreless.
Clevelanders have a soft spot for former Ohio State Buckeyes forward Evan Turner, but they weren't disappointed to see him shoot 2-for-13 from the field and score only four points.
"This is a pretty intense schedule," Young said. "But at the end of the day, as a professional athlete, you have to find ways to get rest and find ways to work yourself back into a rhythm and keep yourself in shape. That's what we're trying to do as a team."
The Sixers were once again without guard Tony Wroten, who has missed the last two games with flu-like symptoms and a migraine.
Cavs point guard Kyrie Irving, out the previous three games with a bruised knee, scored 16 points with eight assists. Center Anderson Varejao scored 18 points, and forward Tristan Thompson and guard Dion Waiters each added 12.
With two big losses behind them, the Sixers know they need to regroup.
"We've got to get our players fresh, we gotta get a little mentally tougher and deal with the realities of the landscape of an NBA season," Brown said. "We will resurface. This group has a side of them that's shown to be resilient. We've taken our hits. They'll come back."
The Sixers waived center Daniel Orton before the game . . . The loss snaps the Sixers' road win streak at four . . . Cleveland's 13 three-pointers marked the 13th time this season a team has hit 13-plus three-pointers against the Sixers, tying an NBA record . . . Entering yesterday, Thaddeus Young had been averaging 25.6 points in his last eight games . . . The Sixers are now 1-14 when failing to score 100 points.