"It is a completely different team," coach Brett Brown said. "I have no idea about the team I just saw the last two nights. The fatigue must have played a far greater factor than I anticipated."
The biggest factor Tuesday night was leaving C.J. Miles unguarded.
The 6-foot-6 shooting guard made 10 of 14 three-pointers to finish with 34 points. He set the Cavs record for made three-pointers in a game. Miles tied the previous record in the first half with eight threes. He made his first six three-point shots.
Although his numbers were impressive, Miles didn't exactly work hard to get open looks. The ninth-year veteran out of Skyline High School in Dallas basically stood unguarded at the three-point line. A defender attempted to run over to guard Miles once the ball swung over to him, but by the time he got close, Miles' shot was on its way into the basket.
His eighth three-pointer gave the Cavs a 64-38 cushion with 36.8 seconds left in the half.
"As a young team, when somebody like that is rolling, you have to be aware of where he is every second," Brown said. "There's a tiny bit that's on us. . . . He got away from us."
Cleveland (12-23) built a commanding 31-point lead in the fourth quarter.
Thaddeus Young of the Sixers failed to score in a regular-season game for the first time since March 12, 2011, against the Milwaukee Bucks.
The Sixers power forward, who sat out most of the second half, missed all seven of his shots in 21 minutes of action.
That's an unlikely performance for someone who was named the Eastern Conference player of the week on Monday. Young had scored at least 17 points in each of the Sixers' previous eight games and averaged 25.6 points during that stretch.
"It was just one of those games where you couldn't get it going," Young said. "I just want to get this one pretty much behind me and move on to the next one.
"But I think we as a team didn't play well. I think the road trip kind of caught up to us a little bit."
The Sixers completed the five-game trip Saturday night, arrived in Philadelphia at 7 a.m. Sunday, and had back-to-back games against Minnesota and Cleveland on Monday and Tuesday.
Rookie point guard Michael Carter-Williams paced the Sixers with a career-high 33 points.
The Cavs welcomed back NBA all-star Kyrie Irving.
The point guard had missed the previous three games with a left knee bruise. He finished with 16 points, eight assists and three blocked shots against the Sixers.
The Cavs traded former Sixer Andrew Bynum to the Chicago Bulls on Monday night in exchange for swingman Luol Deng. The Bulls released Bynum on Tuesday.