Philadelphia police spokeswoman Tanya Little said late Saturday that two firearms were initially thought missing from Jackson's home.
"However, one firearm is missing - a silver, 9mm Ruger with black grips," she wrote in an e-mail.
"We know that a safe has been compromised, and at least $250,000 in cash and jewelry are missing at this time," Little said. "We also have information that a gun safe that was locked with combination and a key was compromised."
No arrests had been made and the investigation was continuing, she said. Torrey Charles Pocock, one of Jackson's publicists, said that he was aware of the burglary but offered no comment
Known for his quickness and explosive play, Jackson was the Eagles' leading receiver this season with 82 catches for 1,332 yards and nine touchdowns. He signed a five-year, $47 million contract that was restructured in March 2012.
Jackson made other news after the Eagles lost to the New Orleans Saints in a wild-card playoff game last weekend. Asked by a reporter Monday about his contract, he said that he was "deserving" of a new deal.
Later that day, Jackson wrote on Instagram that he "didn't ask for a new contract" and that he "was tired of dumb info being twisted."
Inquirer staff writer Jeff McLane contributed to this article.