Wood (41-2) drew within a point of Boykin in the final period, but could never get a clean shot in after that before Boykin iced the win with a takedown in the final seconds.
Boykin, Southeastern Pennsylvania's lone titlist Saturday, is Coatesville's first state champion since Terry Williams (145 pounds) in 1966. Boykin will leave the school with 142 career wins.
"This is every wrestler's dream come true," Boykin said. Going undefeated in your senior year and ending as a state champion. There's nothing better."
The region had five wrestlers vying for gold medals and 16 other medalists taking part in consolation bouts.
Pennridge senior Scott Parker (43-2) fell in the 120 final, on a takedown in overtime, to Greater Latrobe sophomore Luke Pletcher. Parker put up a gritty fight against the undefeated Pletcher, who notched his second consecutive state title at 120.
Father Judge senior Joe Galasso took the mat with Canon McMillan's Solomon Chishko in the 145 final in a battle of defending state-title winners.
Galasso, last year's 138-pound victor, hung with Chishko through two periods but faded late en route to a 7-2 decision.
"I felt pretty good this weekend up until that match," Galasso said. "I couldn't get my shots going, and I just wasn't myself out there tonight. It was his night."
The Cornell recruit will leave Judge with 147 wins and three state medals.
"He's a phenomenal competitor," Judge coach Jim Savage said. "He's placed in the state tournament three times. He's probably one of the best wrestlers, if not the best wrestler, ever in the city of Philadelphia."
Pottsgrove junior Pat Finn (16-4) dropped a 6-1 decision in the heavyweight final to Solanco's Thomas Haines.
In consolation action, North Penn senior Alex Price took a 6-4 victory in the fifth-place match to ice his first career medal-winning state performance. Norristown senior Mike Springer won a 7-2 decision in the 152 fifth-place bout.
Pennridge was the highest team finisher from the region, placing 11th overall. Boyertown finished in 13th place.