The 24-year-old was shot in the neck and a shoulder, and was pronounced dead at Einstein Medical Center at 6:27 p.m., Small said.
The younger man was shot in a leg and was listed in stable condition at Einstein, where he was talking to police, Small said.
Officers found several handguns and rifles behind the house, including possibly an AK-47, Small said.
Police declared a barricade situation, and residents from the north side of Ruscomb opposite the house were evacuated.
Police negotiators eventually coaxed seven males from the house, and they were taken to the Homicide Unit for interrogation, Small said.
"We believe we possibly have the shooter or shooters in that group of seven," Small said.
The second-floor apartment where the men were holed up was being held while police obtained a search warrant, Small said.
Police also seized three dogs from the property and were waiting for animal-control officers.
For part of the barricade, Broad Street from Ruscomb to Rockland Street was shut down in both directions.