Manzano, who had an outstanding career at the Penn Relays competing for Texas, will be part of the DMR.
McCorory and Trotter, members of the U.S. gold-medal-winning 4x400 relay team in the 2012 Olympics, have combined for five victories in the same event at Penn. Wright, the former Tennessee star, is entered in the sprint medley.
The Jamaican contingent for Saturday is expected to include Michael Frater, Kerron Stewart, and Natalya Goule. Some of the world athletes scheduled to compete are Chris Brown of the Bahamas, Dominique Duncan of Nigeria, and Ryan Gregson of Australia.
Penn freshman Noel Jancewicz knew she needed a good 800-meter time to close the Penn Relays heptathlon, and she succeeded in fine style, posting a come-from-behind victory in her first collegiate competition in the grueling seven-event test.
Jancewicz clocked a time of 2 minutes, 20.67 seconds on a windy day at Franklin Field, good for 814 points and a final score of 5,035. She was followed by a pair of freshmen from Northern Illinois - Claudette Day (4,829 points) and Logan Tillmon (4,465).
Day held a 31-point advantage heading into the 800.
"I knew I had to put everything I had into it," Jancewicz said. "My coaches were standing by the 200 marks yelling out my times. I ran 2:17 a couple of weeks ago, but I knew with the wind and doing six events it was going to be tough."
Nick Lebron of Southern Connecticut State, who set an NCAA Division II record last month in winning the national championship in the indoor heptathlon, captured the decathlon.
Lebron posted the fastest time in the day's first event, 14.61 seconds in the 110 hurdles, and had the best marks in the pole vault (14 feet, 3¼ inches) and the 1,500 (4:39.05) en route to 7,160 points.
Buffalo's Kevin Enck took second with 6,647, finishing 20 points ahead of Mike Rabbitt of Cornell.
"It was all right; it was my first one of the year," said Lebron.