Thomas Jefferson University Hospitals will pay $4 million for a five-year deal to put the Jefferson name on SEPTA's Market East commuter rail station in Center City.
For an extra $3.4 million, Jefferson can keep the naming rights for an additional four years - a decision it will make at the end of its initial term.
SEPTA will get 85 percent of the money, and its New York-based advertising agency, Titan Worldwide, will get 15 percent, officials said.
The new Jefferson Station name was unveiled in ceremonies Thursday morning at the 30-year-old subterranean rail hub.
Stephen Klasko, president and CEO of Thomas Jefferson University and Jefferson Health System, said the name would raise Jefferson's presence in the region and demonstrate its desire "to provide access to everyone."