December 9, 2013 |
Three years ago, University of Pennsylvania researchers wondered whether their early success with a novel immune therapy was the dawn of a revolution in cancer treatment - or a fluke. Now they know the answer, and so do other experts in the cautious world of medical science. Penn and Children's Hospital of Philadelphia on Saturday reported the results from 59 adults and children who received a gene therapy engineered from their own disease-fighting T cells to treat recurrent, intractable leukemia.
December 9, 2013 |
From the outset of the study in April 2012, Children's Hospital of Philadelphia was in uncharted territory. So were the parents who consented to give their terminally ill offspring an experimental gene therapy for leukemia. But the little children - 22 and counting - have shown them the way. The first child, as the world learned a year ago, was Emily Whitehead of Philipsburg, Pa. She demonstrated that the bioengineered T cells can have catastrophic side effects, and pointed the way for her doctors to find an antidote drug.
March 30, 2015 |
The sweeping chronicle of cancer that premieres this week on PBS has strong Philadelphia connections. Cancer: The Emperor of All Maladies is famed documentarian Ken Burns' three-part, six-hour film adaptation of the Pulitzer Prize-winning, best-selling book. On Wednesday, the third and final episode prominently features a breakthrough immunotherapy being developed at the University of Pennsylvania and Children's Hospital of Philadelphia in partnership with pharmaceutical giant Novartis.
June 15, 1999 |
The only thing on Timmy Barton's mind most of the time is the video games that he and his father will rent from Blockbuster for his Nintendo. Not the fact that by the end of every week, the 7-year-old will have taken a small mountain of pills. Not the school field trips, baseball games, and weeks of classes that Timmy has missed because of four lengthy hospitalizations in the last 10 months. He rarely talks about that or about the many days he has had to leave school early for chemotherapy.
July 3, 1997 |
The largest and most detailed study conducted on the threat posed by high-tension power lines has found no link between the electromagnetic fields created by the lines and the most common form of childhood leukemia. "There simply wasn't any clear, consistent effect," said Martha Linet, the National Cancer Institute epidemiologist who headed the research group. The findings - based on an evaluation of 1,248 healthy and sick children under age 15 - were reported in today's New England Journal of Medicine.
October 8, 1993 |
This playoff series is about more than baseball for Steve Bedrosian. It is about his 6-year-old son, Cody, who has acute lymphoblastic leukemia. It is about his 8-year-old son, Kyle, who wants to save his brother's life. And maybe can't. It is about his 2-year-old son, Cameron, who doesn't exactly understand what's happening. And who might save Cody. And it is about a telephone call to a hotel room from his wife, Tammy, who is back in Atlanta. The call comes from the hospital where Cody had a good day, a good checkup, with not many leukemic cells left in his blood right now. There's not much hair on his head, either, because chemotherapy does that, but a 6-year-old doesn't worry about it so much.
May 4, 2008 |
Six-year-old Brynn Henry has spent half her life battling leukemia. But on a chilly April Saturday in Glenmoore, Brynn wasn't thinking about her cancer. All she could think about was trying to get the Chincoteague pony she was riding to catch up with her little sister, who was running circles around a barn. Brynn spread her arms out like an airplane as the pony advanced toward the giggling target. With so much of her life out of her control, Brynn, of Coatesville, has found a much-needed escape through horseback riding.
August 20, 1987 |
The medical director of the National Multiple Sclerosis Society has criticized a recent study that indicated a new drug might help MS patients and said he feared a black market could develop for the drug. The drug is a synthetic protein called Copolymer-1 that was developed in Israel. A doctor reported last week in the New England Journal of Medicine that, in a preliminary trial in the United States, the drug appeared effective in alleviating multiple sclerosis' symptoms. Multiple sclerosis is a crippling disease characterized by a slow degeneration of the protective sheath that surrounds nerves, resulting in a gradual loss of muscle control.
April 15, 2013
Small plates make small eaters Everyone who has ever read a diet book knows this tip: Use a smaller plate, and you are likely to put less food on it. Now researchers have found the same is true for children taking food at school lunch. A study showed the "food environment" - conditions around eating - counts, the researchers from universities in Pennsylvania, Ohio and Virginia said. The researchers repeatedly watched 42 first graders serve themselves lunch at school, using plates and bowls of adult size and half as large.
July 11, 2013 |
THIS WEEK comes word that Sarah Murnaghan has pneumonia in her right lung - a condition that her mother, Janet, has described as "definitely a large setback. " Predictably, the online naysayers who comment on our stories are using the news as further evidence that the 10-year-old cystic fibrosis patient never should have undergone transplant surgery that allowed donated adult-size lungs to be surgically altered to fit inside her child-size chest. "Sad though it may be to hear, there's a reason that pediatric patients aren't routinely transplanted with adult lungs: the outcomes tend to be sub-optimal," wrote phillygwm.