August 26, 2016 |
AstraZeneca said Wednesday it will sell its small-molecule antibiotics business to Pfizer in a deal that could be worth $1.5 billion. Pfizer will get rights to some medicines in development and approved antibiotics, including Merrem to treat severe infections of the skin or stomach, Zinforo to treat complicated skin and soft tissue infections, and Zavicefta approved in the European Union for patients with serious bacterial infections. AstraZeneca will receive an upfront payment of $550 million, and a deferred payment of $175 million in January 2019, plus up to $850 million in milestone and sales-related payments.
August 5, 2016
By Andrew F. Read The doctor tried antibiotic after antibiotic, but the bacteria in the woman's body continued to proliferate. With only two drugs left, the doctor asked for my advice. An evolutionary biologist collaborating with the physician to study antibiotic resistance, I suggested he use both drugs simultaneously. I reasoned that since the two drugs had different modes of action, more mutations would be required for the bacteria to generate resistance to both drugs. In truth, we had no idea what to do, and there wasn't enough justification to go with my theory.
July 25, 2016 |
Q: How can I avoid getting a yeast infection when I have to take antibiotics? A: Most women will experience a yeast infection at some point in their lives. According to the U.S. Centers for Disease Control and Prevention, nearly 75 percent of all adult women have had at least one such infection. A healthy vagina is naturally acidic and contains helpful bacteria to fend off infections and maintain a normal pH level. Oftentimes, taking an antibiotic can interfere with this normal balance.
December 14, 2015 |
Although she needed extra calories, Mingo the malnourished stray could swallow only one piece of kibble at a time after being rescued from the streets of Philadelphia's Frankford section two summers ago. Mingo would also hack after drinking, and her bark became raspy. On antibiotics for what seemed like a routine case of kennel cough, the wire-haired, brindle terrier was plucked from the city shelter by the Philadelphia Animal Welfare Society (PAWS), which finds homes for cats and dogs that appear particularly adoptable.
July 24, 2015
ISSUE | IRAN NUKE DEAL In region teeming with violence, hope Although it was not unexpected, the fierce rejection of the nuclear agreement by Israel's prime minister and almost all Republican senators and presidential candidates is disturbing ("Obama's reckless gamble," July 16). While much of the Middle East is a sea of uncontrollable violence, the deal is one example of careful negotiation and compromise. To be sure, this is no grand bargain. It was never intended to change Iranian support of terrorist groups.
July 12, 2015 |
A 43-year-old woman came to a hospital complaining of abdominal pain. She was in poor health generally, with serious kidney disease, insulin-dependent diabetes, vascular disease, and obesity. She also had stomach ulcers, but the pain that brought her to the hospital was like nothing she'd ever experienced. She had been taking antibiotics for a urinary tract infection and developed blisters, which suggested an allergic reaction. Hospital staff quickly found her to be in severe septic shock.
May 24, 2015 |
John, 52, had more infections than anyone else I had ever seen in the 30 years I've been practicing allergy and clinical immunology. At 5-foot-8 and 170 pounds, he didn't look sickly. He dressed in casual clothes and looked relaxed. He had an engaging smile and a firm handshake, and he seemed fit. He looked like he could run a 5K race easily. But after speaking with him for five minutes, I knew something was terribly wrong. At his first visit, John mentioned that he suffered from three to four episodes of sinusitis each year.
January 19, 2015 |
In his sixth year in the NBA, Kyle Lowry - the Villanova University standout who was drafted after his sophomore year, in 2006 - finally had the chance to play regularly. It was now March 2012, and he was a point guard with the Houston Rockets. He knew he could be a star. But that darn pain in his belly was such a distraction. For six months, the tormenting pain below his belly button had shifted from one side to the other. Like many professional athletes, he played through it. Somehow, he could no longer keep the nagging pain out his mind.
December 10, 2014 |
Merck & Co. dove deeper into the antibiotic drug market Monday when it agreed to buy Cubist Pharmaceuticals for $9.5 billion, including debt. The deal would pay Cubist stockholders $102 per share in cash, which Merck calculates is a 35 percent premium to Cubist's average closing price in the preceding five trading days. The agreement includes $8.4 billion for the shares and assumption of about $1.1 billion in company debt. Merck is based in Whitehouse Station, N.J., and has large facilities in Upper Gwynedd and West Point, Montgomery County.
September 8, 2014 |
Antibiotics are an odd category of pharmaceuticals, and Austria-based Nabriva Therapeutics is opening a Philadelphia-area office in hopes of finding a niche in that group. Some antibiotics are used only in humans, some only in animals, but some are used in both. Most adults have come to accept antibiotics so readily that the major problem is overuse. And overuse can mean developing resistance to medicine that used to be very effective. That has prompted efforts to control their use. The New York Times reported Wednesday that the chicken producer Perdue will stop giving antibiotics to its hatching chicks because they will eventually be eaten by humans, thereby contributing to the general problem of antibiotic resistance in humans.