May 14, 2016 |
British drug maker AstraZeneca, with North America headquarters in Wilmington, announced Thursdaythat the Food and Drug Administration has granted Orphan Drug Designation for its MEK inhibitor selumetinib for the treatment of patients with advanced thyroid cancer who fail to respond adequately to radioactive iodine. Orphan Drug status is given to drugs and biologics which treat, diagnose, or prevent rare diseases or disorders that affect fewer than 200,000 U.S. residents. One benefit of Orphan Drug status is a seven-year period of market exclusivity, if the drug is approved.
November 23, 2015 |
WINDHAM, N.H. - Gov. Christie blasted "murderous, radical Islam" and spoke at length of the toll of Sept. 11 while bringing a national security focus to town-hall meetings Saturday in New Hampshire. "This campaign changed eight days ago. It changed," Christie told a packed room at a municipal building in Stratham on Saturday morning, referring to the terror attacks in Paris. "When evil gets visited upon innocent people, the American people react. " Later Saturday, at a town-hall meeting at a bar in a bowling alley, Christie described learning that people he knew had been killed in the Sept.
August 8, 2015 |
One of the most intelligent works on sci-fi ever to hit the small screen, BBC America's Orphan Black , has evolved over its three seasons from a cult favorite to a genuine pop-culture phenomenon. Cocreated by Canadian writer-director John Fawcett ( Ginger Snaps , The Dark ), the series follows, with iron logic, one of those questions that's haunting our culture: What if human cloning became a fact? Tatiana Maslany earned a well-deserved Emmy nomination this year as that clone - well, as an entire series of them.
May 8, 2015
"ORPHAN" is a very empty word, starting with the initial "O" that reminds me of a big, alphabetic hole. It conjures up images of loss, of being rootless, of unwanted and untenable liberty. When I think of "orphan," I think of something flying around in the great human universe, searching for its home. Today, I'm an orphan. That sounds silly, given the fact that I've been able to vote for more than 35 years, which means I'm a very big girl. I pay taxes, own (33 1/3 percent of) a house, take the El by myself and even know how to defrost things.
April 20, 2015
* GAME OF THRONES . 9 p.m. Sunday, HBO. Where's Arya? The younger of the two Stark daughters (Maisie Williams) wasn't in last week's Season 5 premiere, but she's far from forgotten. This weekend, she finally gets off the boat she boarded in last year's finale. * ORPHAN BLACK . 9 p.m. Saturday, BBC America. The storytelling's twistier than ever, and as Season 3 opens Tatiana Maslany continues to dazzle in multiple roles. I might be willing to watch an entire show about her soccer mom clone, Alison (below right, with Kristian Bruun)
April 19, 2015 |
What if you discovered that you were the property of a multinational corporation? That it held exclusive rights to the very essense of your being - your unique genetic code? What if you found out, you weren't born but man-made? That you are one of nine identical people constructed in a lab? That's one of the terrifying truths Sarah Manning (Tatiana Maslany) has to face in BBC America's Orphan Black , a superb, exciting and intelligent sci-fi thriller which returns for its third season 9 p.m. Saturday.
April 10, 2015 |
In 2008, the economic crisis that crashed down on Wall Street and rippled around the globe eventually washed over the impoverished Kisii region of Kenya, where Sara Holby, then 21, was volunteering for a nonprofit that provided food and medicine to HIV/AIDS patients. It swept away the organization's funding almost overnight. "When people came to the office looking for help every day, we basically had nothing to offer them," recalled Holby, who is from Upper Black Eddy, Bucks County.
December 13, 2014 |
In the latest twist in the debate over the future of Girard College, the Board of Directors of City Trusts said Thursday that it would appeal an Orphans' Court decision barring the school from suspending its high school and boarding programs to save money. At the same time, the board pledged to operate the secondary program for four more years to ensure current eighth graders can graduate from the school in 2018-19. "Girard's financial challenges remain unresolved, and there is no doubt that they threaten the long-term survival of the school," board president Ronald R. Donatucci said in a statement.
October 17, 2014 |
The book chosen for the 2015 One Book, One Philadelphia program is the 2013 novel Orphan Train by Christina Baker Kline. To be announced by the Free Library of Philadelphia and the Mayor's Office on Thursday morning, Orphan Train will be the focus of more than 100 art installations, films, performances, discussion groups, and other activities in schools throughout the city. The middle-grade book for 2015 is Rodzina by Karen Cushman, and the children's book is Locomotive by Brian Floca.
September 17, 2014 |
Girard College on Monday asked the city's Orphans' Court to reconsider its recent ruling that the school cannot suspend its high school and boarding programs to improve its finances. The move, one step short of an appeal, came three weeks after Orphans' Court Judge Joseph D. O'Keefe said the boarding and secondary programs were critical parts of the vision the merchant-banker Stephen Girard outlined in his 1831 bequest. The money he left created the free boarding school for poor orphans on a 43-acre site in Fairmount.