June 14, 2015 |
He was a big guy, nearly 300 pounds, so when his left ankle began hurting, the first thing he thought was how much he was asking of it. He'd had a similar pain in his other ankle in the past, even though he swore he hadn't tripped, fallen, twisted, or hurt either one. An orthopedist had sent him to physical therapy the first time, but that only made it much worse. The pain was so severe any movement of the joint was agony, never mind trying to walk on it. Eventually, the pain went away, but now it was his left ankle, which had begun hurting two days ago and was getting worse.
January 25, 2015 |
The patient, a 60-year-old woman, had been battling rheumatoid arthritis for more than a decade. Most of her large joints had been seriously damaged. Both hips, one knee, and a shoulder had been replaced. She took a wide array of medicines, including steroids, but they had failed to stop the illness from progressing. She lacked the strength and dexterity to open a ketchup bottle, and needed family help to complete even small kitchen tasks. Her doctor recommended that she try a new drug known as a "tumor necrosis factor inhibitor," one of the newer "biologics.
November 20, 2014 |
For some of the most common drugs in U.S. medicine cabinets, the time of day they are taken can determine how well they work. That is the conclusion of University of Pennsylvania scientists, who based their finding on an exhaustive, hour-by-hour analysis of the internal protein-generating machinery in mice. Of the nearly 20,000 mouse genes known to contain recipes for making proteins, 43 percent were found to have a clocklike, "circadian" quality, revving up or slowing down their activity level at specific times every day. Almost all of these genes have close equivalents in humans.
June 6, 2014 |
MAYBE it's due to our already long summer of diarrhea jokes, but I developed a soft spot for the clunky bookishness of "Words and Pictures. " This is an inspirational teacher movie in the Mr. Chips/Mr. Holland vein, which doubles down on the inspirational teachers - an English teacher (Clive Owen) and an art teacher (Juliette Binoche) lead a student-body debate on the relative merits of writing and painting. It's also a love story - Jack (Owen) is a blocked writer and an alcoholic, Dina (Binoche)
May 25, 2014 |
After Henry C. McGettigan's mother died when he was 9, he would spend some of his summer days with his maternal grandmother in North Philadelphia. "She would pack a lunch for him" and send him off to Shibe Park at 21st Street and Lehigh Avenue, the home of both the Athletics and the Phillies, daughter Theresa Miller said in a phone interview. "He would go and sit outside and listen to the game," through the roars of the crowds, in the days before portable radios, because he didn't have enough money to buy a ticket.
December 23, 2013 |
WHEN SHE WAS admitted to Immaculate Mary Home two weeks ago, Betty Tyre cried in despair to Deacon Steve Guckin, a member of the pastoral care team. Tyre had been hospitalized so often in 2013, she'd barely slept in her own bed. Rheumatoid arthritis had crippled her so badly, she was in a wheelchair and needed rehab at Immaculate Mary, a Catholic nursing home in Mayfair, before she could return home to Port Richmond. "I feel like I'll never get better," Tyre, 69, told Guckin.
June 9, 2013 |
Big pharmaceutical companies strike licensing deals with small companies in hopes of finding new, highly profitable medicine without the cost of buying a whole company. Small companies get funding other ways, such as venture capital firms, but the money from licensing arrangements can mean the difference between continuing operations and closing shop. Sometimes these deals work, sometimes not. Last week presented four examples, three starting and one ending (badly), involving the drugmakers GlaxoSmithKline, Johnson & Johnson, Pfizer, and AstraZeneca, all of which have significant Philadelphia-area operations.
March 8, 2013 |
JUANITA UPSHUR, 70, doesn't live in an igloo. But for a week in January, the West Mount Airy resident felt as if she did. "It's ice-cold," she said at the time. "You need a coat if you want to go visit somebody in another apartment. " Dorothy Henry, 70, and her husband, Norman, 72, were without heat for three weeks in February. A broken furnace and disagreements with contractors took their toll on the Overbrook Park couple, who said the cold amplified their health problems. Upshur and the Henrys are among dozens of Philadelphia seniors who, according to authorities, have struggled with a lack of heat during some frigid days this winter.
November 7, 2012
LOS ANGELES - Want a clue to your risk of heart disease? Look in the mirror. People who look old have a greater chance of developing heart disease than younger-looking people the same age do, new research suggests. Doctors say the study, presented at an American Heart Association conference, highlights the difference between biological and chronological age. Those with three to four of the aging signs - receding hairline at the temples, baldness at the crown of the head, earlobe creases or yellowish fatty deposits around the eyelids - had a 57 percent greater risk for heart attack and a 39 percent greater risk for heart disease compared to people with none of these signs.
March 29, 2012 |
Adrienne Rich, 82, a poet who for five decades always seemed to be in the vanguard of America's political, social, and literary changes, died Wednesday at her home in Santa Cruz, Calif., from complications of rheumatoid arthritis. Rich was born in Baltimore in 1929. In 1951, while only a senior at Radcliffe College, she published her first book, A Change of World , chosen by W.H. Auden as winner of the Yale Younger Poets Award. One of her most anthologized poems, "Aunt Jennifer's Tiger," is careful, formal, and feminist: "The massive weight of Uncle's wedding band / Lies heavily upon Aunt Jennifer's hand.